論文 - 詳細
| RRC ID | 54024 |
|---|---|
| 著者 | Miyasato Y, Takashima Y, Takeya H, Yano H, Hayano A, Nakagawa T, Makino K, Takeya M, Yamanaka R, Komohara Y. |
| タイトル | The expression of PD-1 ligands and IDO1 by macrophage/microglia in primary central nervous system lymphoma. |
| ジャーナル | J Clin Exp Hematop |
| Abstract |
Recent progress in anti-tumor immunotherapy has focused on the significance of the tumor microenvironment in tumor progression and resistance to chemo/radio-therapy. Myeloid cells such as macrophages are predominant stromal components in hematological malignancies. In the present study, we investigated the regulation of programmed death-1 (PD-1) ligand expression in primary central nervous system lymphoma (PCNSL) using PCNSL cell lines and human monocyte-derived macrophages. TK PCNSL cell line-derived soluble factors induced overexpression of PD-1 ligands, indoleamine 2,3-dioxygenase (IDO1), and several other cytokines in macrophages. The expression of PD-1 ligands was dependent on the activation of signal transducer and activator of transcription 3. PD-L1 and IDO1 were overexpressed by macrophage/microglia in PCNSL tissues, and gene expression profiling indicated that IDO1 expression was positively correlated with the expression of macrophage and lymphocyte markers. Macrophage-derived factors did not influence the proliferation or chemo-sensitivity of cell lines. These data suggest that the expression of immunosuppressive molecules, including PD-1 ligands and IDO1, by macrophage/microglia may be involved in immune evasion of lymphoma cells. |
| 巻・号 | 58(2) |
| ページ | 95-101 |
| 公開日 | 2018-1-1 |
| DOI | 10.3960/jslrt.18001 |
| PMID | 29998979 |
| PMC | PMC6413151 |
| MeSH | B7-H1 Antigen / immunology* Cell Line, Tumor Central Nervous System Neoplasms / immunology* Central Nervous System Neoplasms / pathology Female Gene Expression Regulation, Neoplastic / immunology* Humans Indoleamine-Pyrrole 2,3,-Dioxygenase / immunology* Lymphoma / immunology* Lymphoma / pathology Macrophages / immunology* Macrophages / pathology Male Microglia / immunology* Microglia / pathology Neoplasm Proteins / immunology* Tumor Escape* |
| 引用数 | 12 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HKBML(RCB0820) |