| RRC ID |
54024
|
| 著者 |
Miyasato Y, Takashima Y, Takeya H, Yano H, Hayano A, Nakagawa T, Makino K, Takeya M, Yamanaka R, Komohara Y.
|
| タイトル |
The expression of PD-1 ligands and IDO1 by macrophage/microglia in primary central nervous system lymphoma.
|
| ジャーナル |
J Clin Exp Hematop
|
| Abstract |
Recent progress in anti-tumor immunotherapy has focused on the significance of the tumor microenvironment in tumor progression and resistance to chemo/radio-therapy. Myeloid cells such as macrophages are predominant stromal components in hematological malignancies. In the present study, we investigated the regulation of programmed death-1 (PD-1) ligand expression in primary central nervous system lymphoma (PCNSL) using PCNSL cell lines and human monocyte-derived macrophages. TK PCNSL cell line-derived soluble factors induced overexpression of PD-1 ligands, indoleamine 2,3-dioxygenase (IDO1), and several other cytokines in macrophages. The expression of PD-1 ligands was dependent on the activation of signal transducer and activator of transcription 3. PD-L1 and IDO1 were overexpressed by macrophage/microglia in PCNSL tissues, and gene expression profiling indicated that IDO1 expression was positively correlated with the expression of macrophage and lymphocyte markers. Macrophage-derived factors did not influence the proliferation or chemo-sensitivity of cell lines. These data suggest that the expression of immunosuppressive molecules, including PD-1 ligands and IDO1, by macrophage/microglia may be involved in immune evasion of lymphoma cells.
|
| 巻・号 |
58(2)
|
| ページ |
95-101
|
| 公開日 |
2018-1-1
|
| DOI |
10.3960/jslrt.18001
|
| PMID |
29998979
|
| PMC |
PMC6413151
|
| MeSH |
B7-H1 Antigen / immunology*
Cell Line, Tumor
Central Nervous System Neoplasms / immunology*
Central Nervous System Neoplasms / pathology
Female
Gene Expression Regulation, Neoplastic / immunology*
Humans
Indoleamine-Pyrrole 2,3,-Dioxygenase / immunology*
Lymphoma / immunology*
Lymphoma / pathology
Macrophages / immunology*
Macrophages / pathology
Male
Microglia / immunology*
Microglia / pathology
Neoplasm Proteins / immunology*
Tumor Escape*
|
| 引用数 |
12
|
| リソース情報 |
| ヒト・動物細胞 |
HKBML(RCB0820) |
