論文 - 詳細
| RRC ID | 54171 |
|---|---|
| 著者 | Bin Saifullah MA, Nagai T, Kuroda K, Wulaer B, Nabeshima T, Kaibuchi K, Yamada K. |
| タイトル | Cell type-specific activation of mitogen-activated protein kinase in D1 receptor-expressing neurons of the nucleus accumbens potentiates stimulus-reward learning in mice. |
| ジャーナル | Sci Rep |
| Abstract |
Medium spiny neurons (MSN) in the nucleus accumbens (NAc) are a fundamental component of various aspects of motivated behavior. Although mitogen-activated protein kinase (MAPK) signaling plays a crucial role in several types of learning, the cell type-specific role of MAPK pathway in stimulus-reward learning and motivation remains unclear. We herein investigated the role of MAPK in accumbal MSNs in reward-associated learning and memory. During the acquisition of Pavlovian conditioning, the number of phosphorylated MAPK1/3-positive cells was increased significantly and exclusively in the NAc core by 7-days of extensive training. MAPK signaling in the respective D1R- and D2R-MSNs was manipulated by transfecting an adeno-associated virus (AAV) plasmid into the NAc of Drd1a-Cre and Drd2-Cre transgenic mice. Potentiation of MAPK signaling shifted the learning curve of Pavlovian conditioning to the left only in Drd1a-Cre mice, whereas such manipulation in D2R-MSNs had negligible effects. In contrast, MAPK manipulation in D2R-MSNs of the NAc core significantly increased motivation for food rewards as found in Drd1a-Cre mice. These results suggest that MAPK signaling in the D1R-MSNs of NAc core plays an important role in stimulus-reward learning, while MAPK signaling in both D1R- and D2R-MSNs is involved in motivation for natural rewards. |
| 巻・号 | 8(1) |
| ページ | 14413 |
| 公開日 | 2018-9-26 |
| DOI | 10.1038/s41598-018-32840-1 |
| PII | 10.1038/s41598-018-32840-1 |
| PMID | 30258218 |
| PMC | PMC6158283 |
| MeSH | Animals Conditioning, Classical Dopaminergic Neurons / cytology Dopaminergic Neurons / metabolism* Learning* MAP Kinase Signaling System* Male Mice, Inbred C57BL Motivation Nucleus Accumbens / cytology* Nucleus Accumbens / physiology Phosphorylation Receptors, Dopamine D1 / metabolism* Receptors, Dopamine D2 / metabolism Reward |
| IF | 3.998 |
| 引用数 | 1 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC02332 RBRC03111 |