論文 - 詳細
| RRC ID | 54275 |
|---|---|
| 著者 | Ohshiro T, Saigo K. |
| タイトル | Transcriptional regulation of breathless FGF receptor gene by binding of TRACHEALESS/dARNT heterodimers to three central midline elements in Drosophila developing trachea. |
| ジャーナル | Development |
| Abstract |
The development of Drosophila trachea is under the control of spatially and/or quantitatively regulated activity of BREATHLESS FGF receptor, which is also essential for midline glial migration. Here, we identified the minimum enhancer region of breathless, cloned the Drosophila ARNT gene (dARNT), and showed biochemical and genetic evidence that breathless expression in developing trachea is regulated by direct interactions between TRACHEALESS/dARNT heterodimers and three central midline elements (TACGTGs) situated in the minimum enhancer region. Our results also showed that SINGLE-MINDED/dARNT heterodimers, which are essential for breathless expression in midline precursor cells, share DNA targets in common with TRACHEALESS/dARNT, indicating that two different basic helix-loop-helix-PAS protein complexes act through the same target sites in vivo. |
| 巻・号 | 124(20) |
| ページ | 3975-86 |
| 公開日 | 1997-10-1 |
| DOI | 10.1242/dev.124.20.3975 |
| PMID | 9374395 |
| MeSH | Amino Acid Sequence Animals Aryl Hydrocarbon Receptor Nuclear Translocator Base Sequence DNA-Binding Proteins* Drosophila / embryology* Drosophila / genetics* Drosophila Proteins* Enhancer Elements, Genetic / genetics* Gene Expression Regulation, Developmental* Molecular Sequence Data Protein-Tyrosine Kinases* Receptors, Aryl Hydrocarbon* Receptors, Fibroblast Growth Factor / genetics* Sequence Alignment Trachea / embryology Transcription Factors / genetics* Transcription, Genetic* |
| IF | 5.611 |
| 引用数 | 106 |
| リソース情報 | |
| ショウジョウバエ | |