| RRC ID |
54290
|
| 著者 |
Sakai T, Sasaki M, Kataoka-Sasaki Y, Oka S, Nakazaki M, Fukumura S, Kobayashi M, Tsutsumi H, Kocsis JD, Honmou O.
|
| タイトル |
Functional recovery after the systemic administration of mesenchymal stem cells in a rat model of neonatal hypoxia-ischemia.
|
| ジャーナル |
J Neurosurg Pediatr
|
| Abstract |
The authors intravenously infused mesenchymal stem cells (MSCs) into a rat model of neonatal hypoxia-ischemia and found improvements in functional outcome, increased brain volume, and enhanced synaptogenesis. The results of this animal study suggest that the intravenous administration of MSCs should be further explored as a potential treatment for patients suffering from cerebral palsy after hypoxic-ischemic encephalopathy.
|
| 巻・号 |
22(5)
|
| ページ |
513-522
|
| 公開日 |
2018-11-1
|
| DOI |
10.3171/2018.5.PEDS1845
|
| PII |
2018.5.PEDS1845
|
| PMID |
30074448
|
| MeSH |
Animals
Brain / physiopathology*
Disease Models, Animal
Hypoxia-Ischemia, Brain / physiopathology
Hypoxia-Ischemia, Brain / therapy*
Mesenchymal Stem Cell Transplantation*
Rats
Rats, Sprague-Dawley
Recovery of Function / physiology*
|
| IF |
2.162
|
| 引用数 |
1
|
| リソース情報 |
| ラット |
W-Tg(CAG-GFP)184Ys (strainID=525) |
