論文 - 詳細
| RRC ID | 54364 |
|---|---|
| 著者 | Lebreton G, Géminard C, Lapraz F, Pyrpassopoulos S, Cerezo D, Spéder P, Ostap EM, Noselli S. |
| タイトル | Molecular to organismal chirality is induced by the conserved myosin 1D. |
| ジャーナル | Science |
| Abstract |
The emergence of asymmetry from an initially symmetrical state is a universal transition in nature. Living organisms show asymmetries at the molecular, cellular, tissular, and organismal level. However, whether and how multilevel asymmetries are related remains unclear. In this study, we show that Drosophila myosin 1D (Myo1D) and myosin 1C (Myo1C) are sufficient to generate de novo directional twisting of cells, single organs, or the whole body in opposite directions. Directionality lies in the myosins' motor domain and is swappable between Myo1D and Myo1C. In addition, Myo1D drives gliding of actin filaments in circular, counterclockwise paths in vitro. Altogether, our results reveal the molecular motor Myo1D as a chiral determinant that is sufficient to break symmetry at all biological scales through chiral interaction with the actin cytoskeleton. |
| 巻・号 | 362(6417) |
| ページ | 949-952 |
| 公開日 | 2018-11-23 |
| DOI | 10.1126/science.aat8642 |
| PII | 362/6417/949 |
| PMID | 30467170 |
| PMC | PMC6698710 |
| MeSH | Actin Cytoskeleton / chemistry* Animals Drosophila Proteins / antagonists & inhibitors Drosophila Proteins / chemistry* Drosophila melanogaster / growth & development Isomerism Larva Models, Molecular* Myosin Type I / antagonists & inhibitors Myosin Type I / chemistry* Myosin Type V / chemistry Protein Domains |
| IF | 41.846 |
| 引用数 | 22 |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 179 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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