| Abstract |
We investigated the effects of pregnancy experience on ovarian senescence and longevity using two inbred strains of Hatano rats. These strains have been selectively bred for high- and low-avoidance animals (HAA and LAA, respectively), but the HAA line has a slower onset of ovarian senescence and a shorter lifespan compared with the LAA line. The onset of abnormal estrous cycles and survival curves were compared between nulliparous and parous rats in each line. In the HAA line, pregnancy experience did not change the onset of ovarian senescence but increased longevity. This suggests that a pituitary tumor, which is a causal factor for accelerated mortality in this line, developed slowly in parous rats. In the LAA line, pregnancy experience delayed the onset of ovarian senescence and reduced the incidence of mammary tumors but did not increase longevity because of an increased frequency of constipation with megacolon. These data suggest that the effects of pregnancy experience on ovarian senescence and longevity depend on the reproductive characteristics of the rat strains.
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