RRC ID 54380
Author Matsukage A, Nishikawa K, Ooi T, Seto Y, Yamaguchi M.
Title Homology between mammalian DNA polymerase beta and terminal deoxynucleotidyltransferase.
Journal J Biol Chem
Abstract Nucleotide sequence analysis of the cDNA and the genomic clones for rat DNA polymerase beta revealed the existence of a 1,005-base pair open reading frame capable of encoding a Mr = 38,269 polypeptide of 335 amino acid residues. The region of 174 amino acid residues between the 42nd and 215th residues of the DNA polymerase beta polypeptide has extensive amino acid sequence homology with the region between the 195th and 366th residues of human terminal deoxynucleotidyltransferase. The two enzymes share extensive homology not only in primary structures but also in the computer-derived higher structures in these particular regions. The genes for DNA polymerase beta and terminal deoxynucleotidyltransferase are proposed to be derived from a common ancestral DNA polymerase gene.
Volume 262(19)
Pages 8960-2
Published 1987-7-5
PII S0021-9258(18)48029-5
PMID 3597402
MeSH Amino Acid Sequence Animals DNA Polymerase I / analysis* DNA Polymerase I / genetics DNA-Directed DNA Polymerase / analysis* DNA-Directed DNA Polymerase / genetics Humans Macromolecular Substances Protein Conformation Rats
IF 4.238
Times Cited 73
DNA material Rat DNA polymerase beta cDNA (RDB01355)