| RRC ID |
54537
|
| Author |
Horio N, Murata K, Yoshikawa K, Yoshihara Y, Touhara K.
|
| Title |
Contribution of individual olfactory receptors to odor-induced attractive or aversive behavior in mice.
|
| Journal |
Nat Commun
|
| Abstract |
Odorants are recognized by multiple olfactory receptors (ORs) and induce innate behaviors like attraction or aversion via olfactory system in mice. However, a role of an individual OR is unclear. Muscone is recognized by a few ORs including MOR215-1 and MOR214-3, and attracts male mice. Odor preference tests using MOR215-1 knockout mice revealed that MOR215-1 and other OR(s), possibly including MOR214-3, are involved in the attraction. (Z)-5-tetradecen-1-ol (Z5-14:OH) activates ~3 ORs, including Olfr288, and evokes attraction at low levels but aversion at higher levels. Olfr288 knockout mice show no attraction but aversion, suggesting Olfr288 is involved in preference for Z5-14:OH, whereas activation of other low-affinity Z5-14:OH receptors evokes aversion. Each OR appears to send a signal to a neural circuit that possesses distinct valence, leading to a certain behavior. The final output behavior with multiple ORs stimulation is determined by summation (addition or competition) of valences coded by activated ORs.
|
| Volume |
10(1)
|
| Pages |
209
|
| Published |
2019-1-14
|
| DOI |
10.1038/s41467-018-07940-1
|
| PII |
10.1038/s41467-018-07940-1
|
| PMID |
30643144
|
| PMC |
PMC6331590
|
| MeSH |
Animals
Cycloparaffins / chemistry
Cycloparaffins / metabolism
Female
Instinct*
Male
Mating Preference, Animal / physiology*
Mice
Mice, Inbred C57BL
Mice, Knockout
Odorants
Olfactory Receptor Neurons / physiology*
Receptors, Odorant / physiology*
Smell / physiology*
|
| IF |
11.878
|
| Times Cited |
4
|
| Resource |
| DNA material |
B6N Mouse BAC clone B6Ng01-336J02 (RDB07573) |
