RRC ID 54538
著者 Chen KF, Lowe S, Lamaze A, Krätschmer P, Jepson J.
タイトル Neurocalcin regulates nighttime sleep and arousal in Drosophila.
ジャーナル Elife
Abstract Sleep-like states in diverse organisms can be separated into distinct stages, each with a characteristic arousal threshold. However, the molecular pathways underlying different sleep stages remain unclear. The fruit fly, Drosophila melanogaster, exhibits consolidated sleep during both day and night, with night sleep associated with higher arousal thresholds compared to day sleep. Here we identify a role for the neuronal calcium sensor protein Neurocalcin (NCA) in promoting sleep during the night but not the day by suppressing nocturnal arousal and hyperactivity. We show that both circadian and light-sensing pathways define the temporal window in which NCA promotes sleep. Furthermore, we find that NCA promotes sleep by suppressing synaptic release from a dispersed wake-promoting neural network and demonstrate that the mushroom bodies, a sleep-regulatory center, are a module within this network. Our results advance the understanding of how sleep stages are genetically defined.
巻・号 8
公開日 2019-3-13
DOI 10.7554/eLife.38114
PII 38114
PMID 30865587
PMC PMC6415939
MeSH Animals Arousal* Drosophila melanogaster / physiology* Mushroom Bodies / drug effects Mushroom Bodies / physiology Nerve Net / drug effects Nerve Net / physiology Neurocalcin / metabolism* Sleep*
IF 7.551
引用数 1
リソース情報
ショウジョウバエ 7674R-1 7674R-2