| RRC ID |
54546
|
| 著者 |
Yamada S, Kimura M, Saito Y, Saito H.
|
| タイトル |
Nrf2-mediated anti-oxidant effects contribute to suppression of non-alcoholic steatohepatitis-associated hepatocellular carcinoma in murine model.
|
| ジャーナル |
J Clin Biochem Nutr
|
| Abstract |
The exact mechanisms of hepatocellular carcinoma development in non-alcoholic steatohepatitis remain unclear. In this study, we used a new class of high-fat diet, which could induce hepatocellular carcinoma development without the use of general chemical carcinogens or knockout mice. We investigated the correlation between hepatocellular carcinoma and oxidative stress/anti-oxidant effects after depletion of the gut microbiota by treatment with antibiotics. Mice fed with the steatohepatitis-inducing high-fat diet (STHD-01) for 41 weeks developed hepatocellular carcinoma. Antibiotic-treatment in mice fed with STHD-01 significantly depleted the gut microbiota and significantly ameliorated liver injury/histology. The tumor numbers of hepatocellular carcinoma were dramatically decreased by the antibiotics-treatment. We analyzed the factors involved in oxidative stress and anti-oxidant effects. Oxidative stress was elevated in mice fed with STHD-01, whereas some anti-oxidant factors were significantly elevated after antibiotics treatment. These results suggest that the gut microbiota is a key factor in improving oxidative stress induced by STHD-01 feeding.
|
| 巻・号 |
63(2)
|
| ページ |
123-128
|
| 公開日 |
2018-9-1
|
| DOI |
10.3164/jcbn.17-125
|
| PII |
jcbn17-125
|
| PMID |
30279623
|
| PMC |
PMC6160730
|
| IF |
2.19
|
| 引用数 |
0
|
| リソース情報 |
| 遺伝子材料 |
Genomic DNA of Escherichia coli JCM 1649 T (JGD12168) |
