| RRC ID |
54773
|
| 著者 |
Takahashi A, Wakihata S, Ma L, Adachi T, Hirose H, Yoshida Y, Ohira Y.
|
| タイトル |
Temporary Loading Prevents Cancer Progression and Immune Organ Atrophy Induced by Hind-Limb Unloading in Mice.
|
| ジャーナル |
Int J Mol Sci
|
| Abstract |
Although the body's immune system is altered during spaceflight, the effects of microgravity (μG) on tumor growth and carcinogenesis are, as yet, unknown. To assess tumor proliferation and its effects on the immune system, we used a hind-limb unloading (HU) murine model to simulate μG during spaceflight. HU mice demonstrated significantly increased tumor growth, metastasis to the lung, and greater splenic and thymic atrophy compared with mice in constant orthostatic suspension and standard housing controls. In addition, mice undergoing temporary loading during HU (2 h per day) demonstrated no difference in cancer progression and immune organ atrophy compared with controls. Our findings suggest that temporary loading can prevent cancer progression and immune organ atrophy induced by HU. Further space experiment studies are warranted to elucidate the precise effects of μG on systemic immunity and cancer progression.
|
| 巻・号 |
19(12)
|
| 公開日 |
2018-12-9
|
| DOI |
10.3390/ijms19123959
|
| PII |
ijms19123959
|
| PMID |
30544854
|
| PMC |
PMC6321260
|
| MeSH |
Animals
Atrophy
Body Weight
Cell Line, Tumor
Disease Progression*
Hindlimb Suspension*
Lung Neoplasms / secondary
Lymphoid Tissue / pathology
Mice
Neoplasms / pathology*
Organ Specificity*
|
| IF |
4.183
|
| 引用数 |
1
|
| リソース情報 |
| ヒト・動物細胞 |
LM8(RCB1450) |
