| RRC ID |
54791
|
| 著者 |
Nakamura Y, Nakahata S, Kondo Y, Izumi A, Yamamoto K, Ichikawa T, Tamura T, Noumi K, Yamashita Y, Morishita K.
|
| タイトル |
Overexpression of absent in melanoma 2 in oral squamous cell carcinoma contributes to tumor progression.
|
| ジャーナル |
Biochem Biophys Res Commun
|
| Abstract |
We had previously reported that in addition to p53 inactivation, overexpression of the DNA sensor protein-absent in melanoma 2 (AIM2)-contributes to tumorigenesis of oral squamous cell carcinoma (OSCC). Given that AIM2 is highly expressed in the OSCC tumors from patients with metastasis, we investigated whether AIM2 expression contributes to the progression of OSCC metastasis. In in vitro assays using OSCC cell lines, the high migration and invasion capacity of OSCC cells were dependent on the increased expression of AIM2, resulting in enhanced epithelial-mesenchymal transition (EMT), with EMT-related gene expression. Moreover, the in vivo short-term metastasis assay using orthotopic implantation into immunodeficient mice demonstrated that OSCC cells with high levels of AIM2 expression exhibited enhanced tumor growth in the tongue, resulting in decreased survival of the mice. Further, the cells overexpressing AIM2 dominantly invaded into the tumor lymphatic vessels, unlike OSCC cells with low AIM2 expression. Thus, the high expression of AIM2 in OSCC enhances progression of tumor growth.
|
| 巻・号 |
509(1)
|
| ページ |
82-88
|
| 公開日 |
2019-1-29
|
| DOI |
10.1016/j.bbrc.2018.12.066
|
| PII |
S0006-291X(18)32709-8
|
| PMID |
30587341
|
| MeSH |
Animals
Carcinoma, Squamous Cell / genetics*
Carcinoma, Squamous Cell / pathology
Cell Line, Tumor
Cell Movement
DNA-Binding Proteins / genetics*
Disease Progression
Epithelial-Mesenchymal Transition
Female
Gene Expression Regulation, Neoplastic*
Humans
Mice
Mouth Neoplasms / genetics*
Mouth Neoplasms / pathology
Neoplasm Invasiveness / genetics
Neoplasm Invasiveness / pathology
Up-Regulation*
Uterine Cervical Neoplasms / genetics
Uterine Cervical Neoplasms / pathology
Uterine Cervical Neoplasms / secondary
|
| IF |
2.705
|
| 引用数 |
1
|
| リソース情報 |
| ヒト・動物細胞 |
HSC-2(RCB1945)
HSC-3(RCB1975)
HSC-4(RCB1902)
Sa3(RCB0980)
Ca9-22(RCB1976)
SAS(RCB1974)
Ho-1-u-1(RCB2102)
HSQ-89(RCB0789) |
