論文 - 詳細
| RRC ID | 54822 |
|---|---|
| 著者 | Win NN, Kyaw MM, Prema, Ngwe H, Ito T, Asakawa Y, Okamoto Y, Tanaka M, Abe I, Morita H. |
| タイトル | Dinorcassane Diterpenoid from Boesenbergia rotunda Rhizomes Collected in Lower Myanmar. |
| ジャーナル | Chem Biodivers |
| Abstract |
A new dinorcassane diterpenoid, seikphoochinal A (1), and four known compounds, pinostrobin (2), 4',7-dimethylkaempferol (3), and galanals A (4) and B (5), were isolated from the chloroform-soluble crude extract of wild type Boesenbergia rotunda rhizomes collected in Lower Myanmar. The chemical structures of these compounds were identified, using a combination of spectroscopic methods. The presence of the diterpenoids 1, 4, and 5 demonstrated the structural diversity of wild type B. rotunda. Among the isolates, compounds 4 and 5 exhibited significant antiproliferative activities against a small panel of human cancer cell lines, including lung (LK-2, A549), stomach (ECC4), breast (MCF7), cervix (HeLa), and prostate (DU145). |
| 巻・号 | 16(4) |
| ページ | e1800657 |
| 公開日 | 2019-4-1 |
| DOI | 10.1002/cbdv.201800657 |
| PMID | 30645035 |
| MeSH | Antineoplastic Agents, Phytogenic / chemistry Antineoplastic Agents, Phytogenic / isolation & purification Antineoplastic Agents, Phytogenic / pharmacology* Cell Line, Tumor Cell Proliferation / drug effects Diterpenes / chemistry Diterpenes / isolation & purification Diterpenes / pharmacology* Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Humans Molecular Structure Myanmar Plant Extracts / chemistry Plant Extracts / isolation & purification Plant Extracts / pharmacology* Structure-Activity Relationship Zingiberaceae / chemistry* |
| IF | 1.449 |
| 引用数 | 1 |
| リソース情報 | |
| ヒト・動物細胞 | A549(RCB3677) ECC4(RCB0982) HeLa(RCB3680) DU145(RCB2143) MCF7(RCB1904) |