RRC ID 54847
Author Abdelrhman Y, Gepreel MA, Kobayashi S, Okano S, Okamoto T.
Title Biocompatibility of new low-cost (α + β)-type Ti-Mo-Fe alloys for long-term implantation.
Journal Mater Sci Eng C Mater Biol Appl
Abstract In this work, two new α + β titanium alloys with low contents of ubiquitous and low-cost alloying elements (i.e., Mo and Fe) were designed on the basis of the electronic parameters and molybdenum equivalent approaches. The designed Ti - 2Mo - 0.5Fe at. % (TMF6) and Ti - 3Mo - 0.5Fe at. % (TMF8) alloys were produced using arc melting process for studying their mechanical, electrochemical and cytotoxicity compatibilities and comparing these compatibilities to those of Ti-6Al-4V ELI alloy. The cost of the used raw materials for producing the TMF6 and TMF8 alloys are almost 1/6 of those for producing the Ti-6Al-4V ELI alloy. The hardness of the two alloys are higher than that of the Ti-6Al-4V ELI alloy, while their Young's moduli (in the range of 85-82 GPa) are lower than that of the Ti-6Al-4V ELI alloy (110 GPa). Increasing the Mo equivalent from 6 (in TMF6 alloy) to 8 (in TMF8 alloy) led to an increase in the plastic strain percent from 4% to 17%, respectively, and a decrease in the ultimate tensile strength from 949 MPa to 800 MPa, respectively. The microstructure of TMF6 alloy consists of α'/α″ phases, while TMF8 alloy substantially consists of α″ phase. The corrosion current densities and the film resistances of the new alloys are in the range of 0.70-1.07 nA/cm2 and on the order of 105 Ω·cm2, respectively. These values are more compatible with biomedical applications than those measured for the Ti-6Al-4V ELI alloy. Furthermore, the cell viabilities of the TMF6 and TMF8 alloys indicate their improved compatibility compared to that of the Ti-6Al-4V ELI alloy. The CCK-8 (Cell Counting Kit-8) assay was conducted to investigate the cytotoxicity, proliferation, and shape index of the cells of the candidate alloys. Overall, the measured compatibility of the new V-free low-cost alloys, particularly TMF8, makes them promising candidates for replacing the Ti-6Al-4V ELI alloy in biomedical applications.
Volume 99
Pages 552-562
Published 2019-6
DOI 10.1016/j.msec.2019.01.133
PII S0928-4931(18)30948-2
PMID 30889729
MeSH Alloys / economics Alloys / pharmacology* Animals Biocompatible Materials / economics* Biocompatible Materials / pharmacology* Cell Death / drug effects Cell Line Cell Shape / drug effects Cell Size / drug effects Cell Survival / drug effects Corrosion Costs and Cost Analysis* Cytoskeleton / drug effects Cytoskeleton / metabolism Dielectric Spectroscopy Elastic Modulus Electrochemical Techniques Hardness Iron / pharmacology* Mice Molybdenum / pharmacology* Prosthesis Implantation* Stress, Mechanical Tensile Strength Titanium / pharmacology* X-Ray Diffraction
IF 4.959
Human and Animal Cells MC3T3-E1(RCB1126)