論文 - 詳細
| RRC ID | 54847 |
|---|---|
| 著者 | Abdelrhman Y, Gepreel MA, Kobayashi S, Okano S, Okamoto T. |
| タイトル | Biocompatibility of new low-cost (α + β)-type Ti-Mo-Fe alloys for long-term implantation. |
| ジャーナル | Mater Sci Eng C Mater Biol Appl |
| Abstract |
In this work, two new α + β titanium alloys with low contents of ubiquitous and low-cost alloying elements (i.e., Mo and Fe) were designed on the basis of the electronic parameters and molybdenum equivalent approaches. The designed Ti - 2Mo - 0.5Fe at. % (TMF6) and Ti - 3Mo - 0.5Fe at. % (TMF8) alloys were produced using arc melting process for studying their mechanical, electrochemical and cytotoxicity compatibilities and comparing these compatibilities to those of Ti-6Al-4V ELI alloy. The cost of the used raw materials for producing the TMF6 and TMF8 alloys are almost 1/6 of those for producing the Ti-6Al-4V ELI alloy. The hardness of the two alloys are higher than that of the Ti-6Al-4V ELI alloy, while their Young's moduli (in the range of 85-82 GPa) are lower than that of the Ti-6Al-4V ELI alloy (110 GPa). Increasing the Mo equivalent from 6 (in TMF6 alloy) to 8 (in TMF8 alloy) led to an increase in the plastic strain percent from 4% to 17%, respectively, and a decrease in the ultimate tensile strength from 949 MPa to 800 MPa, respectively. The microstructure of TMF6 alloy consists of α'/α″ phases, while TMF8 alloy substantially consists of α″ phase. The corrosion current densities and the film resistances of the new alloys are in the range of 0.70-1.07 nA/cm2 and on the order of 105 Ω·cm2, respectively. These values are more compatible with biomedical applications than those measured for the Ti-6Al-4V ELI alloy. Furthermore, the cell viabilities of the TMF6 and TMF8 alloys indicate their improved compatibility compared to that of the Ti-6Al-4V ELI alloy. The CCK-8 (Cell Counting Kit-8) assay was conducted to investigate the cytotoxicity, proliferation, and shape index of the cells of the candidate alloys. Overall, the measured compatibility of the new V-free low-cost alloys, particularly TMF8, makes them promising candidates for replacing the Ti-6Al-4V ELI alloy in biomedical applications. |
| 巻・号 | 99 |
| ページ | 552-562 |
| 公開日 | 2019-6-1 |
| DOI | 10.1016/j.msec.2019.01.133 |
| PII | S0928-4931(18)30948-2 |
| PMID | 30889729 |
| MeSH | Alloys / economics Alloys / pharmacology* Animals Biocompatible Materials / economics* Biocompatible Materials / pharmacology* Cell Death / drug effects Cell Line Cell Shape / drug effects Cell Size / drug effects Cell Survival / drug effects Corrosion Costs and Cost Analysis* Cytoskeleton / drug effects Cytoskeleton / metabolism Dielectric Spectroscopy Elastic Modulus Electrochemical Techniques Hardness Iron / pharmacology* Mice Molybdenum / pharmacology* Prosthesis Implantation* Stress, Mechanical Tensile Strength Titanium / pharmacology* X-Ray Diffraction |
| IF | 4.959 |
| 引用数 | 7 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-E1(RCB1126) |