Reference - Detail
| RRC ID | 54895 |
|---|---|
| Author | Takagi Y, Kikuchi T, Niimura M, Ohno T. |
| Title | Anti-tumor effects of dendritic and tumor cell fusions are not dependent on expression of MHC class I and II by dendritic cells. |
| Journal | Cancer Lett |
| Abstract |
Vaccination of fusion cells (FCs) made from dendritic and tumor cells elicits anti-tumor effects. We investigated whether major histocompatibility complex (MHC) class I and II play an important role in the induction of anti-tumor immunity by FCs. Immunization with fusion cells composed of syngeneic, allogeneic, or MHC I(-/-)II(-/-) DCs and B16 cells inhibited tumor growth. Elispot assay showed a higher population of interferon-gamma secreting T lymphocytes in mice immunized with fusion cells. These data suggest that anti-tumor effects of DCs and tumor cell fusions are not dependent on the expression of MHC class I and II on DCs. |
| Volume | 213(1) |
| Pages | 49-55 |
| Published | 2004-9-15 |
| DOI | 10.1016/j.canlet.2004.04.010 |
| PII | S0304383504003179 |
| PMID | 15312683 |
| MeSH | Animals Cancer Vaccines / immunology* Dendritic Cells / immunology* Female Genes, MHC Class I* Genes, MHC Class II* HLA Antigens / biosynthesis Immunotherapy / methods Melanoma / immunology* Melanoma / pathology Mice Mice, Inbred C57BL Mice, Knockout Neoplasms, Experimental Skin Neoplasms / immunology* Skin Neoplasms / pathology Tumor Cells, Cultured / immunology* |
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| Total number of mentions | 0 |
| Resource | |
| Human and Animal Cells | B16 |