| RRC ID |
54895
|
| Author |
Takagi Y, Kikuchi T, Niimura M, Ohno T.
|
| Title |
Anti-tumor effects of dendritic and tumor cell fusions are not dependent on expression of MHC class I and II by dendritic cells.
|
| Journal |
Cancer Lett
|
| Abstract |
Vaccination of fusion cells (FCs) made from dendritic and tumor cells elicits anti-tumor effects. We investigated whether major histocompatibility complex (MHC) class I and II play an important role in the induction of anti-tumor immunity by FCs. Immunization with fusion cells composed of syngeneic, allogeneic, or MHC I(-/-)II(-/-) DCs and B16 cells inhibited tumor growth. Elispot assay showed a higher population of interferon-gamma secreting T lymphocytes in mice immunized with fusion cells. These data suggest that anti-tumor effects of DCs and tumor cell fusions are not dependent on the expression of MHC class I and II on DCs.
|
| Volume |
213(1)
|
| Pages |
49-55
|
| Published |
2004-9-15
|
| DOI |
10.1016/j.canlet.2004.04.010
|
| PII |
S0304383504003179
|
| PMID |
15312683
|
| MeSH |
Animals
Cancer Vaccines / immunology*
Dendritic Cells / immunology*
Female
Genes, MHC Class I*
Genes, MHC Class II*
HLA Antigens / biosynthesis
Immunotherapy / methods
Melanoma / immunology*
Melanoma / pathology
Mice
Mice, Inbred C57BL
Mice, Knockout
Neoplasms, Experimental
Skin Neoplasms / immunology*
Skin Neoplasms / pathology
Tumor Cells, Cultured / immunology*
|
| Resource |
| Human and Animal Cells |
B16 |
