論文 - 詳細
| RRC ID | 54997 |
|---|---|
| 著者 | Hiscock TW, Miesfeld JB, Mosaliganti KR, Link BA, Megason SG. |
| タイトル | Feedback between tissue packing and neurogenesis in the zebrafish neural tube. |
| ジャーナル | Development |
| Abstract |
Balancing the rate of differentiation and proliferation in developing tissues is essential to produce organs of robust size and composition. Although many molecular regulators have been established, how these connect to physical and geometrical aspects of tissue architecture is poorly understood. Here, using high-resolution timelapse imaging, we find that changes to cell geometry associated with dense tissue packing play a significant role in regulating differentiation rate in the zebrafish neural tube. Specifically, progenitors that are displaced away from the apical surface due to crowding, tend to differentiate in a Notch-dependent manner. Using simulations we show that interplay between progenitor density, cell shape and changes in differentiation rate could naturally result in negative-feedback control on progenitor cell number. Given these results, we suggest a model whereby differentiation rate is regulated by density dependent effects on cell geometry to: (1) correct variability in cell number; and (2) balance the rates of proliferation and differentiation over development to 'fill' the available space. |
| 巻・号 | 145(9) |
| 公開日 | 2018-5-4 |
| DOI | 10.1242/dev.157040 |
| PII | dev.157040 |
| PMID | 29678815 |
| PMC | PMC5992593 |
| MeSH | Animals Cell Differentiation / physiology* Cell Proliferation / physiology* Neural Stem Cells / cytology Neural Stem Cells / metabolism* Neural Tube / cytology Neural Tube / embryology* Neurogenesis / physiology* Receptors, Notch / genetics Receptors, Notch / metabolism Zebrafish / embryology* Zebrafish / genetics Zebrafish Proteins / genetics Zebrafish Proteins / metabolism |
| IF | 5.763 |
| 引用数 | 5 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg (Huc:Kaede) |