Reference - Detail
| RRC ID | 55011 |
|---|---|
| Author | Rulands S, Iglesias-Gonzalez AB, Boije H. |
| Title | Deterministic fate assignment of Müller glia cells in the zebrafish retina suggests a clonal backbone during development. |
| Journal | Eur J Neurosci |
| Abstract |
The optic cup houses multipotent retinal progenitor cells that proliferate and differentiate to form the mature retina, containing five main types of neurons and a single glial cell type, the Müller cell. Progenitors of the zebrafish optic cup generate clones that vary regarding the number and types of neurons, a process we previously showed could be described by stochastic models. Here, we present data indicating that each retinal progenitor cell, in the 24 hrs post-fertilization optic cup, is predestined to form a single Müller cell. This striking fate assignment of Müller cells reveals a dual nature of retinal lineages where stochastic mechanisms produce variable numbers of neurons while there is a strong deterministic component governing the formation of glia cells. A possible mechanism for this stereotypic fate assignment could be the maintenance of a clonal backbone during retina development, which would be similar to invertebrate and rodent cortical neurogenesis. |
| Volume | 48(12) |
| Pages | 3597-3605 |
| Published | 2018-12-1 |
| DOI | 10.1111/ejn.14257 |
| PMID | 30408243 |
| PMC | PMC6588021 |
| MeSH | Animals Animals, Genetically Modified / genetics Cell Differentiation / physiology Cell Proliferation / physiology Ependymoglial Cells / metabolism* Neurogenesis / physiology Neuroglia / metabolism* Neurons / metabolism Retina / metabolism* Stem Cells / metabolism* Zebrafish / metabolism Zebrafish Proteins / metabolism |
| IF | 2.784 |
| Times Cited | 0 |
| Altmetric score |
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Zebrafish | Tg(chx10:GFP) |