Reference - Detail
| RRC ID | 55055 |
|---|---|
| Author | Kumar M, Mathur T, Joshi V, Upadhyay DJ, Inoue SI, Masuda N. |
| Title | Effect of DS-2969b, a novel GyrB inhibitor, on rat and monkey intestinal microbiota. |
| Journal | Anaerobe |
| Abstract |
DS-2969b, a novel GyrB inhibitor, transiently and reversibly altered the counts of limited intestinal microbiota at around 10 μg/g of faecal levels in rats and monkeys. Considering the high activity of DS-2969b against Clostridium difficile, 10 μg/g of faecal levels would be sufficient for clearing C. difficile from the intestine. |
| Volume | 51 |
| Pages | 120-123 |
| Published | 2018-6-1 |
| DOI | 10.1016/j.anaerobe.2018.04.017 |
| PII | S1075-9964(18)30074-X |
| PMID | 29758524 |
| MeSH | Animals Bacterial Load Clostridioides difficile / drug effects DNA Gyrase / metabolism* Feces / microbiology Gastrointestinal Microbiome / drug effects* Haplorhini Rats Topoisomerase II Inhibitors / administration & dosage* |
| IF | 2.704 |
| Times Cited | 4 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 5 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| General Microbes | JCM 1255 |