| RRC ID |
55055
|
| Author |
Kumar M, Mathur T, Joshi V, Upadhyay DJ, Inoue SI, Masuda N.
|
| Title |
Effect of DS-2969b, a novel GyrB inhibitor, on rat and monkey intestinal microbiota.
|
| Journal |
Anaerobe
|
| Abstract |
DS-2969b, a novel GyrB inhibitor, transiently and reversibly altered the counts of limited intestinal microbiota at around 10 μg/g of faecal levels in rats and monkeys. Considering the high activity of DS-2969b against Clostridium difficile, 10 μg/g of faecal levels would be sufficient for clearing C. difficile from the intestine.
|
| Volume |
51
|
| Pages |
120-123
|
| Published |
2018-6-1
|
| DOI |
10.1016/j.anaerobe.2018.04.017
|
| PII |
S1075-9964(18)30074-X
|
| PMID |
29758524
|
| MeSH |
Animals
Bacterial Load
Clostridioides difficile / drug effects
DNA Gyrase / metabolism*
Feces / microbiology
Gastrointestinal Microbiome / drug effects*
Haplorhini
Rats
Topoisomerase II Inhibitors / administration & dosage*
|
| IF |
2.704
|
| Times Cited |
4
|
| Resource |
| General Microbes |
JCM 1255 |
