Reference - Detail
| RRC ID | 55165 |
|---|---|
| Author | Gao X, Mu P, Wen J, Sun Y, Chen Q, Deng Y. |
| Title | Detoxification of trichothecene mycotoxins by a novel bacterium, Eggerthella sp. DII-9. |
| Journal | Food Chem Toxicol |
| Abstract |
Trichothecene mycotoxins are a group of structurally related sesquiterpenoid metabolites produced by multiple Fusarium species that often contaminate cereals and threaten human and animal health. The basic structure of this mycotoxin group is a characteristic 12, 13-epoxide group, which is considered an essential functional group for toxicity. In this study, using trichothecene mycotoxin deoxynivalenol (DON) as a representative substrate, we identified a novel trichothecene deepoxidation bacterium, Eggerthella sp. DII-9 (DII-9), from chicken intestines. DII-9 can grow and transform DON over abroad range of temperatures (20-45 °C) and pH values (5-10), suggesting the possibility of developing promising future applications as feed additives. Substrate specificity analysis showed that DII-9 is capable of promoting the deepoxidation of DON, HT-2, T-2 triol and T-2 tetraol. To explore the molecular mechanisms of the de-epoxidation of trichothecenes, the complete genome of DII-9 was sequenced and characterized. Altogether, a novel detoxification bacterium for trichothecene mycotoxins was identified and characterized. |
| Volume | 112 |
| Pages | 310-319 |
| Published | 2018-2-1 |
| DOI | 10.1016/j.fct.2017.12.066 |
| PII | S0278-6915(17)30816-5 |
| PMID | 29294345 |
| MeSH | Actinobacteria / classification Actinobacteria / genetics Actinobacteria / isolation & purification* Actinobacteria / metabolism* Animals Biodegradation, Environmental Chickens Intestines / microbiology* Mass Spectrometry Mycotoxins / chemistry Mycotoxins / metabolism* Phylogeny Trichothecenes / chemistry Trichothecenes / metabolism* |
| IF | 3.775 |
| Times Cited | 10 |
| Altmetric score |
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| General Microbes | JCM 9979 |