論文 - 詳細
| RRC ID | 55427 |
|---|---|
| 著者 | Abe H, Kawada M, Igarashi M, Ohba SI, Hayashi C, Sakashita C, Watanabe T, Shibasaki M. |
| タイトル | Biological activity of intervenolin analogs with a phenyl substituent. |
| ジャーナル | J Antibiot (Tokyo) |
| Abstract |
Intervenolin analogs with a phenyl substituent at the 2- or 3-position were synthesized. The compounds (3-11) showed weak or no inhibitory activity toward the growth of MKN-74 gastric adenocarcinoma cells, even in the presence or absence of the corresponding Hs738 stromal cells, whereas 2-substituted analogs exhibited selective anti-Helicobacter pylori activity. Introduction of a pendant side chain on the nitrogen alleviated their acute toxicity in mice. The 2-phenyl-substituted analogs are reasonable structural templates for structure-activity relationship studies toward the development of anti-H. pylori agents that do not affect human cells.The Journal of Antibiotics advance online publication, 11 October 2017; doi:10.1038/ja.2017.123. |
| 公開日 | 2017-10-11 |
| DOI | 10.1038/ja.2017.123 |
| PII | ja2017123 |
| PMID | 29018268 |
| IF | 2.446 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 12093 JCM 12095 JCM 2529 JCM 5803 |
| ヒト・動物細胞 | MKN74(RCB1002) |