| RRC ID |
55427
|
| 著者 |
Abe H, Kawada M, Igarashi M, Ohba SI, Hayashi C, Sakashita C, Watanabe T, Shibasaki M.
|
| タイトル |
Biological activity of intervenolin analogs with a phenyl substituent.
|
| ジャーナル |
J Antibiot (Tokyo)
|
| Abstract |
Intervenolin analogs with a phenyl substituent at the 2- or 3-position were synthesized. The compounds (3-11) showed weak or no inhibitory activity toward the growth of MKN-74 gastric adenocarcinoma cells, even in the presence or absence of the corresponding Hs738 stromal cells, whereas 2-substituted analogs exhibited selective anti-Helicobacter pylori activity. Introduction of a pendant side chain on the nitrogen alleviated their acute toxicity in mice. The 2-phenyl-substituted analogs are reasonable structural templates for structure-activity relationship studies toward the development of anti-H. pylori agents that do not affect human cells.The Journal of Antibiotics advance online publication, 11 October 2017; doi:10.1038/ja.2017.123.
|
| 公開日 |
2017-10-11
|
| DOI |
10.1038/ja.2017.123
|
| PII |
ja2017123
|
| PMID |
29018268
|
| IF |
2.446
|
| リソース情報 |
| 一般微生物 |
JCM 12093
JCM 12095
JCM 2529
JCM 5803 |
| ヒト・動物細胞 |
MKN74(RCB1002) |
