RRC ID 55433
Author Dadashipour M, Iwamoto M, Hossain MM, Akutsu JI, Zhang Z, Kawarabayasi Y.
Title Identification of a Direct Biosynthetic Pathway for UDP-N-Acetylgalactosamine from Glucosamine-6-Phosphate in Thermophilic Crenarchaeon Sulfolobus tokodaii.
Journal J. Bacteriol.
Abstract species lacking all three pathways were found, predicting the presence of one more unknown pathway. Identification of these novel proteins and pathways provides important insights into the evolution of nucleotide sugar biosynthesis, as well as being potentially important industrially.
Volume 200(10)
Published 2018-5-15
DOI 10.1128/JB.00048-18
PII JB.00048-18
PMID 29507091
PMC PMC5915783
MeSH Acetylgalactosamine / biosynthesis* Acetyltransferases / genetics Acetyltransferases / metabolism Archaeal Proteins / genetics Archaeal Proteins / metabolism* Biosynthetic Pathways Galactosamine / analogs & derivatives Galactosamine / metabolism Glucosamine / analogs & derivatives Glucosamine / metabolism Glucose-6-Phosphate / analogs & derivatives Glucose-6-Phosphate / metabolism Glucosephosphates / metabolism Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) / genetics Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) / metabolism* Phosphates / metabolism Phosphoglucomutase / genetics Phosphoglucomutase / metabolism* Sulfolobus / enzymology* Sulfolobus / genetics Uridine Diphosphate N-Acetylglucosamine / biosynthesis*
IF 3.219
Resource
General Microbes JCM 10545