論文 - 詳細
| RRC ID | 55496 |
|---|---|
| 著者 | Arai S, Iwabuchi N, Takahashi S, Xiao JZ, Abe F, Hachimura S. |
| タイトル | Orally administered heat-killed Lactobacillus paracasei MCC1849 enhances antigen-specific IgA secretion and induces follicular helper T cells in mice. |
| ジャーナル | PLoS One |
| Abstract |
Antigen-specific immunoglobulin (Ig) A plays a major role in host defense against infections in gut mucosal tissue. Follicular helper T (Tfh) cells are located in germinal centers and promote IgA production via interactions with germinal center B cells. Several studies have demonstrated that some lactic acid bacteria (LAB) strains activate the host's acquired immune system, inducing IgA secretion in the intestine. However, the precise molecular mechanisms underlying the effects of LAB on IgA production and Tfh cells are not fully resolved. Lactobacillus paracasei MCC1849 is a probiotic strain isolated from the intestine of a healthy adult. In this study, we investigated the effects of orally administered heat-killed MCC1849 on IgA production in the intestine and on Tfh cell induction in vivo. We found that orally administered MCC1849 induced antigen-specific IgA production in the small intestine, serum and lungs. We also observed that MCC1849 increased the proportion of IgA+ B cells and Tfh cells in Peyer's patches (PPs). In addition, MCC1849 increased the gene expression of IL-12p40, IL-10, IL-21, STAT4 and Bcl-6 associated with Tfh cell differentiation. These results suggest that orally administered MCC1849 enhances antigen-specific IgA production and likely affects Tfh cell differentiation in PPs. |
| 巻・号 | 13(6) |
| ページ | e0199018 |
| 公開日 | 2018-6-13 |
| DOI | 10.1371/journal.pone.0199018 |
| PII | PONE-D-17-34634 |
| PMID | 29897995 |
| PMC | PMC5999281 |
| MeSH | Administration, Oral Animals B-Lymphocytes / cytology B-Lymphocytes / metabolism Cell Differentiation Cytokines / analysis Cytokines / metabolism Hot Temperature Immunoglobulin A, Secretory / blood Immunoglobulin A, Secretory / metabolism* Influenza A Virus, H1N1 Subtype / pathogenicity Intestine, Small / metabolism Lacticaseibacillus paracasei / immunology* Lung / metabolism Male Mice Mice, Inbred BALB C Orthomyxoviridae Infections / prevention & control Ovalbumin / immunology Peyer's Patches / metabolism Probiotics / administration & dosage Proto-Oncogene Proteins c-bcl-6 / metabolism T-Lymphocytes, Helper-Inducer / cytology T-Lymphocytes, Helper-Inducer / immunology* T-Lymphocytes, Helper-Inducer / metabolism |
| IF | 2.776 |
| 引用数 | 9 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 14 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 1248 JCM 1134 JCM 1112 JCM 1185 JCM 8130 JCM 1120 |