論文 - 詳細
| RRC ID | 55507 |
|---|---|
| 著者 | Kawashima T, Ikari N, Kouchi T, Kowatari Y, Kubota Y, Shimojo N, Tsuji NM. |
| タイトル | The molecular mechanism for activating IgA production by Pediococcus acidilactici K15 and the clinical impact in a randomized trial. |
| ジャーナル | Sci Rep |
| Abstract |
IgA secretion at mucosal sites is important for host defence against pathogens as well as maintaining the symbiosis with microorganisms present in the small intestine that affect IgA production. In the present study, we tested the ability of 5 strains of lactic acid bacteria stimulating IgA production, being Pediococcus acidilactici K15 selected as the most effective on inducing this protective immunoglobulin. We found that this response was mainly induced via IL-10, as efficiently as IL-6, secreted by K15-stimulated dendritic cells. Furthermore, bacterial RNA was largely responsible for the induction of these cytokines; double-stranded RNA was a major causative molecule for IL-6 production whereas single-stranded RNA was critical factor for IL-10 production. In a randomized, double-blind, placebo-controlled clinical trial, ingestion of K15 significantly increased the secretory IgA (sIgA) concentration in saliva compared with the basal level observed before this intervention. These results indicate that functional lactic acid bacteria induce IL-6 and IL-10 production by dendritic cells, which contribute to upregulating the sIgA concentration at mucosal sites in humans. |
| 巻・号 | 8(1) |
| ページ | 5065 |
| 公開日 | 2018-3-22 |
| DOI | 10.1038/s41598-018-23404-4 |
| PII | 10.1038/s41598-018-23404-4 |
| PMID | 29567956 |
| PMC | PMC5864838 |
| MeSH | Adult Animals Dendritic Cells / metabolism Dendritic Cells / microbiology Female Gastric Mucosa / metabolism Gastric Mucosa / microbiology Humans Immunoglobulin A, Secretory / biosynthesis* Immunoglobulin A, Secretory / metabolism Interleukin-10 / biosynthesis* Interleukin-10 / genetics Interleukin-6 / biosynthesis* Interleukin-6 / genetics Intestine, Small / metabolism* Intestine, Small / microbiology Lactobacillales / immunology Lactobacillales / metabolism Male Middle Aged Pediococcus acidilactici / immunology Pediococcus acidilactici / metabolism* RNA, Bacterial / genetics RNA, Bacterial / metabolism RNA, Double-Stranded / genetics RNA, Double-Stranded / metabolism Saliva / metabolism Saliva / microbiology |
| IF | 4.011 |
| 引用数 | 13 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 1149 JCM 1558 JCM 1002 |