RRC ID 55613
著者 Lee B, Barretto EC, Grewal SS.
タイトル TORC1 modulation in adipose tissue is required for organismal adaptation to hypoxia in Drosophila.
ジャーナル Nat Commun
Abstract Animals often develop in environments where conditions such as food, oxygen and temperature fluctuate. The ability to adapt their metabolism to these fluctuations is important for normal development and viability. In most animals, low oxygen (hypoxia) is deleterious. However some animals can alter their physiology to tolerate hypoxia. Here we show that TORC1 modulation in adipose tissue is required for organismal adaptation to hypoxia in Drosophila. We find that hypoxia rapidly suppresses TORC1 signaling in Drosophila larvae via TSC-mediated inhibition of Rheb. We show that this hypoxia-mediated inhibition of TORC1 specifically in the larval fat body is essential for viability. Moreover, we find that these effects of TORC1 inhibition on hypoxia tolerance are mediated through remodeling of fat body lipid storage. These studies identify the larval adipose tissue as a key hypoxia-sensing tissue that coordinates whole-body development and survival to changes in environmental oxygen by modulating TORC1 and lipid metabolism.
巻・号 10(1)
ページ 1878
公開日 2019-4-23
DOI 10.1038/s41467-019-09643-7
PII 10.1038/s41467-019-09643-7
PMID 31015407
PMC PMC6478872
MeSH Acclimatization / physiology* Adipose Tissue / metabolism* Animals Animals, Genetically Modified DNA-Binding Proteins / genetics Drosophila / physiology* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Hypoxia / metabolism* Larva / growth & development Lipid Droplets / physiology Lipid Metabolism / physiology Ras Homolog Enriched in Brain Protein / metabolism Transcription Factors / genetics Transcription Factors / metabolism*
IF 11.878
引用数 4
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