Reference - Detail
|Author||Sajeevan SE, Chatterjee M, Paul V, Baranwal G, Kumar VA, Bose C, Banerji A, Nair BG, Prasanth BP, Biswas R.|
|Title||Impregnation of catheters with anacardic acid from cashew nut shell prevents Staphylococcus aureus biofilm development.|
|Journal||J Appl Microbiol|
AIM:The effect of anacardic acid impregnation on catheter surfaces for the prevention of Staphylococcus aureus attachments and biofilm formations were evaluated.
METHODS AND RESULTS:Silicon catheter tubes were impregnated using different concentrations of anacardic acids (0·002-0·25%). Anacardic acids are antibacterial phenolic lipids from cashew nut (Anacardium occidentale) shell oil. Anacardic acid-impregnated silicon catheters revealed no significant haemolytic activity and were cytocompatible against fibroblast cell line (L929). Sustained release of anacardic acids was observed for 4 days. Anacardic acid-impregnated silicon catheters efficiently inhibited S. aureus colonization and the biofilm formation on its surface. The in vivo antibiofilm activity of anacardic acid-impregnated catheters was tested in an intraperitoneal catheter-associated medaka fish infection model. Significant reduction in S. aureus colonization on anacardic acid-impregnated catheter tubes was observed.
CONCLUSIONS:Our data suggest that anacardic acid-impregnated silicon catheters may help in preventing catheter-related staphylococcal infections.
SIGNIFICANCE AND IMPACT OF THE STUDY:This study opens new directions for designing antimicrobial phytochemical-coated surfaces with ideal antibiofilm properties and could be of great interest for biomedical research scientists.
|MeSH||Anacardic Acids / pharmacology* Anacardium / chemistry* Anti-Bacterial Agents / pharmacology* Biofilms / drug effects* Staphylococcus aureus / drug effects*|