RRC ID 55706
Author Sajeevan SE, Chatterjee M, Paul V, Baranwal G, Kumar VA, Bose C, Banerji A, Nair BG, Prasanth BP, Biswas R.
Title Impregnation of catheters with anacardic acid from cashew nut shell prevents Staphylococcus aureus biofilm development.
Journal J Appl Microbiol
Abstract AIM:The effect of anacardic acid impregnation on catheter surfaces for the prevention of Staphylococcus aureus attachments and biofilm formations were evaluated.
METHODS AND RESULTS:Silicon catheter tubes were impregnated using different concentrations of anacardic acids (0·002-0·25%). Anacardic acids are antibacterial phenolic lipids from cashew nut (Anacardium occidentale) shell oil. Anacardic acid-impregnated silicon catheters revealed no significant haemolytic activity and were cytocompatible against fibroblast cell line (L929). Sustained release of anacardic acids was observed for 4 days. Anacardic acid-impregnated silicon catheters efficiently inhibited S. aureus colonization and the biofilm formation on its surface. The in vivo antibiofilm activity of anacardic acid-impregnated catheters was tested in an intraperitoneal catheter-associated medaka fish infection model. Significant reduction in S. aureus colonization on anacardic acid-impregnated catheter tubes was observed.
CONCLUSIONS:Our data suggest that anacardic acid-impregnated silicon catheters may help in preventing catheter-related staphylococcal infections.
SIGNIFICANCE AND IMPACT OF THE STUDY:This study opens new directions for designing antimicrobial phytochemical-coated surfaces with ideal antibiofilm properties and could be of great interest for biomedical research scientists.
Volume 125(5)
Pages 1286-1295
Published 2018-11-1
DOI 10.1111/jam.14040
PMID 29972893
MeSH Anacardic Acids / pharmacology* Anacardium / chemistry* Anti-Bacterial Agents / pharmacology* Biofilms / drug effects* Staphylococcus aureus / drug effects*
IF 2.16
Times Cited 5
Medaka Qurt (MT828)