論文 - 詳細
| RRC ID | 55706 |
|---|---|
| 著者 | Sajeevan SE, Chatterjee M, Paul V, Baranwal G, Kumar VA, Bose C, Banerji A, Nair BG, Prasanth BP, Biswas R. |
| タイトル | Impregnation of catheters with anacardic acid from cashew nut shell prevents Staphylococcus aureus biofilm development. |
| ジャーナル | J Appl Microbiol |
| Abstract |
AIM:The effect of anacardic acid impregnation on catheter surfaces for the prevention of Staphylococcus aureus attachments and biofilm formations were evaluated. METHODS AND RESULTS:Silicon catheter tubes were impregnated using different concentrations of anacardic acids (0·002-0·25%). Anacardic acids are antibacterial phenolic lipids from cashew nut (Anacardium occidentale) shell oil. Anacardic acid-impregnated silicon catheters revealed no significant haemolytic activity and were cytocompatible against fibroblast cell line (L929). Sustained release of anacardic acids was observed for 4 days. Anacardic acid-impregnated silicon catheters efficiently inhibited S. aureus colonization and the biofilm formation on its surface. The in vivo antibiofilm activity of anacardic acid-impregnated catheters was tested in an intraperitoneal catheter-associated medaka fish infection model. Significant reduction in S. aureus colonization on anacardic acid-impregnated catheter tubes was observed. CONCLUSIONS:Our data suggest that anacardic acid-impregnated silicon catheters may help in preventing catheter-related staphylococcal infections. SIGNIFICANCE AND IMPACT OF THE STUDY:This study opens new directions for designing antimicrobial phytochemical-coated surfaces with ideal antibiofilm properties and could be of great interest for biomedical research scientists. |
| 巻・号 | 125(5) |
| ページ | 1286-1295 |
| 公開日 | 2018-11-1 |
| DOI | 10.1111/jam.14040 |
| PMID | 29972893 |
| MeSH | Anacardic Acids / pharmacology* Anacardium / chemistry* Anti-Bacterial Agents / pharmacology* Biofilms / drug effects* Staphylococcus aureus / drug effects* |
| IF | 2.16 |
| 引用数 | 5 |
| リソース情報 | |
| メダカ | Qurt (MT828) |