| RRC ID |
55709
|
| 著者 |
Shao L, Chung P, Wong A, Siwanowicz I, Kent CF, Long X, Heberlein U.
|
| タイトル |
A Neural Circuit Encoding the Experience of Copulation in Female Drosophila.
|
| ジャーナル |
Neuron
|
| Abstract |
Female behavior changes profoundly after mating. In Drosophila, the mechanisms underlying the long-term changes led by seminal products have been extensively studied. However, the effect of the sensory component of copulation on the female's internal state and behavior remains elusive. We pursued this question by dissociating the effect of coital sensory inputs from those of male ejaculate. We found that the sensory inputs of copulation cause a reduction of post-coital receptivity in females, referred to as the "copulation effect." We identified three layers of a neural circuit underlying this phenomenon. Abdominal neurons expressing the mechanosensory channel Piezo convey the signal of copulation to female-specific ascending neurons, LSANs, in the ventral nerve cord. LSANs relay this information to neurons expressing myoinhibitory peptides in the brain. We hereby provide a neural mechanism by which the experience of copulation facilitates females encoding their mating status, thus adjusting behavior to optimize reproduction.
|
| 巻・号 |
102(5)
|
| ページ |
1025-1036.e6
|
| 公開日 |
2019-6-5
|
| DOI |
10.1016/j.neuron.2019.04.009
|
| PII |
S0896-6273(19)30344-7
|
| PMID |
31072787
|
| MeSH |
Abdomen
Animals
Brain / metabolism*
Brain / physiology
Copulation / physiology*
Drosophila Proteins / metabolism*
Drosophila Proteins / physiology
Drosophila melanogaster
Female
Ganglia, Sensory / metabolism
Ganglia, Sensory / physiology
Ion Channels / metabolism*
Ion Channels / physiology
Mechanotransduction, Cellular / physiology*
Neural Pathways
Neurons / metabolism*
Neurons / physiology
Sexual Behavior, Animal / physiology
|
| IF |
14.403
|
| 引用数 |
6
|
| リソース情報 |
| ショウジョウバエ |
8486R–3 |
