論文 - 詳細
| RRC ID | 55745 |
|---|---|
| 著者 | Chao ZC, Sawada M, Isa T, Nishimura Y. |
| タイトル | Dynamic Reorganization of Motor Networks During Recovery from Partial Spinal Cord Injury in Monkeys. |
| ジャーナル | Cereb Cortex |
| Abstract |
After spinal cord injury (SCI), the motor-related cortical areas can be a potential substrate for functional recovery in addition to the spinal cord. However, a dynamic description of how motor cortical circuits reorganize after SCI is lacking. Here, we captured the comprehensive dynamics of motor networks across SCI in a nonhuman primate model. Using electrocorticography over the sensorimotor areas in monkeys, we collected broadband neuronal signals during a reaching-and-grasping task at different stages of recovery of dexterous finger movements after a partial SCI at the cervical levels. We identified two distinct network dynamics: grasping-related intrahemispheric interactions from the contralesional premotor cortex (PM) to the contralesional primary motor cortex (M1) in the high-γ band (>70 Hz), and motor-preparation-related interhemispheric interactions from the contralesional to ipsilesional PM in the α and low-β bands (10-15 Hz). The strengths of these networks correlated to the time course of behavioral recovery. The grasping-related network showed enhanced activation immediately after the injury, but gradually returned to normal while the strength of the motor-preparation-related network gradually increased. Our findings suggest a cortical compensatory mechanism after SCI, where two interdependent motor networks redirect activity from the contralesional hemisphere to the other hemisphere to facilitate functional recovery. |
| 巻・号 | 29(7) |
| ページ | 3059-3073 |
| 公開日 | 2019-7-5 |
| DOI | 10.1093/cercor/bhy172 |
| PII | 5060284 |
| PMID | 30060105 |
| MeSH | Animals Efferent Pathways / physiopathology* Functional Laterality / physiology* Macaca Motor Cortex / physiopathology* Recovery of Function / physiology* Spinal Cord Injuries / physiopathology* |
| IF | 5.437 |
| 引用数 | 4 |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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| ニホンザル | |