Reference - Detail
| RRC ID | 55749 |
|---|---|
| Author | Kunimatsu J, Suzuki TW, Ohmae S, Tanaka M. |
| Title | Different contributions of preparatory activity in the basal ganglia and cerebellum for self-timing. |
| Journal | Elife |
| Abstract |
The ability to flexibly adjust movement timing is important for everyday life. Although the basal ganglia and cerebellum have been implicated in monitoring of supra- and sub-second intervals, respectively, the underlying neuronal mechanism remains unclear. Here, we show that in monkeys trained to generate a self-initiated saccade at instructed timing following a visual cue, neurons in the caudate nucleus kept track of passage of time throughout the delay period, while those in the cerebellar dentate nucleus were recruited only during the last part of the delay period. Conversely, neuronal correlates of trial-by-trial variation of self-timing emerged earlier in the cerebellum than the striatum. Local inactivation of respective recording sites confirmed the difference in their relative contributions to supra- and sub-second intervals. These results suggest that the basal ganglia may measure elapsed time relative to the intended interval, while the cerebellum might be responsible for the fine adjustment of self-timing. |
| Volume | 7 |
| Published | 2018-7-2 |
| DOI | 10.7554/eLife.35676 |
| PII | 35676 |
| PMID | 29963985 |
| PMC | PMC6050043 |
| MeSH | Action Potentials / physiology* Animals Caudate Nucleus / anatomy & histology Caudate Nucleus / cytology Caudate Nucleus / physiology* Cerebellar Nuclei / anatomy & histology Cerebellar Nuclei / cytology Cerebellar Nuclei / physiology* Electrodes, Implanted Female Macaca Neurons / cytology Neurons / physiology* Organ Specificity Photic Stimulation Psychomotor Performance / physiology Reaction Time / physiology* Saccades / physiology* Single-Cell Analysis / methods Time Factors |
| IF | 7.551 |
| Times Cited | 12 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 17 |
| Altmetric score changes over past 6months | 0.2 |
| Resource | |
| Japanese macaques | |