RRC ID 55759
Author Noritake A, Ninomiya T, Isoda M.
Title Social reward monitoring and valuation in the macaque brain.
Journal Nat Neurosci
Abstract Behaviors are influenced by rewards to both oneself and others, but the neurons and neural connections that monitor and evaluate rewards in social contexts are unknown. To address this issue, we devised a social Pavlovian conditioning procedure for pairs of monkeys. Despite being constant in amount and probability, the subjective value of forthcoming self-rewards, as indexed by licking and choice behaviors, decreased as partner-reward probability increased. This value modulation was absent when the conspecific partner was replaced by a physical object. Medial prefrontal cortex neurons selectively monitored self-reward and partner-reward information, whereas midbrain dopaminergic neurons integrated this information into a subjective value. Recordings of local field potentials revealed that responses to reward-predictive stimuli in medial prefrontal cortex started before those in dopaminergic midbrain nuclei and that neural information flowed predominantly in a medial prefrontal cortex-to-midbrain direction. These findings delineate a dedicated pathway for subjective reward evaluation in social environments.
Volume 21(10)
Pages 1452-1462
Published 2018-10-1
DOI 10.1038/s41593-018-0229-7
PII 10.1038/s41593-018-0229-7
PMID 30224807
MeSH Action Potentials / physiology Animals Brain / cytology Brain / physiology* Brain Mapping* Choice Behavior / physiology Conditioning, Classical / physiology* Feeding Behavior / physiology Fixation, Ocular / physiology Macaca fascicularis Male Neurons / physiology Photic Stimulation Reaction Time / physiology Reward* Social Behavior*
IF 21.126
Times Cited 14
Japanese macaques