| RRC ID |
55759
|
| 著者 |
Noritake A, Ninomiya T, Isoda M.
|
| タイトル |
Social reward monitoring and valuation in the macaque brain.
|
| ジャーナル |
Nat Neurosci
|
| Abstract |
Behaviors are influenced by rewards to both oneself and others, but the neurons and neural connections that monitor and evaluate rewards in social contexts are unknown. To address this issue, we devised a social Pavlovian conditioning procedure for pairs of monkeys. Despite being constant in amount and probability, the subjective value of forthcoming self-rewards, as indexed by licking and choice behaviors, decreased as partner-reward probability increased. This value modulation was absent when the conspecific partner was replaced by a physical object. Medial prefrontal cortex neurons selectively monitored self-reward and partner-reward information, whereas midbrain dopaminergic neurons integrated this information into a subjective value. Recordings of local field potentials revealed that responses to reward-predictive stimuli in medial prefrontal cortex started before those in dopaminergic midbrain nuclei and that neural information flowed predominantly in a medial prefrontal cortex-to-midbrain direction. These findings delineate a dedicated pathway for subjective reward evaluation in social environments.
|
| 巻・号 |
21(10)
|
| ページ |
1452-1462
|
| 公開日 |
2018-10-1
|
| DOI |
10.1038/s41593-018-0229-7
|
| PII |
10.1038/s41593-018-0229-7
|
| PMID |
30224807
|
| MeSH |
Action Potentials / physiology
Animals
Brain / cytology
Brain / physiology*
Brain Mapping*
Choice Behavior / physiology
Conditioning, Classical / physiology*
Feeding Behavior / physiology
Fixation, Ocular / physiology
Macaca fascicularis
Male
Neurons / physiology
Photic Stimulation
Reaction Time / physiology
Reward*
Social Behavior*
|
| IF |
21.126
|
| 引用数 |
14
|
| リソース情報 |
| ニホンザル |
|
