論文 - 詳細
| RRC ID | 55874 |
|---|---|
| 著者 | Ezcurra M, Benedetto A, Sornda T, Gilliat AF, Au C, Zhang Q, van Schelt S, Petrache AL, Wang H, de la Guardia Y, Bar-Nun S, Tyler E, Wakelam MJ, Gems D. |
| タイトル | C. elegans Eats Its Own Intestine to Make Yolk Leading to Multiple Senescent Pathologies. |
| ジャーナル | Curr Biol |
| Abstract |
Aging (senescence) is characterized by the development of numerous pathologies, some of which limit lifespan. Key to understanding aging is discovery of the mechanisms (etiologies) that cause senescent pathology. In C. elegans, a major senescent pathology of unknown etiology is atrophy of its principal metabolic organ, the intestine. Here we identify a cause of not only this pathology but also of yolky lipid accumulation and redistribution (a form of senescent obesity): autophagy-mediated conversion of intestinal biomass into yolk. Inhibiting intestinal autophagy or vitellogenesis rescues both visceral pathologies and can also extend lifespan. This defines a disease syndrome leading to multimorbidity and contributing to late-life mortality. Activation of gut-to-yolk biomass conversion by insulin/IGF-1 signaling (IIS) promotes reproduction and senescence. This illustrates how major, IIS-promoted senescent pathologies in C. elegans can originate not from damage accumulation but from direct effects of futile, continued action of a wild-type biological program (vitellogenesis). |
| 巻・号 | 28(16) |
| ページ | 2544-2556.e5 |
| 公開日 | 2018-8-20 |
| DOI | 10.1016/j.cub.2018.06.035 |
| PII | S0960-9822(18)30826-1 |
| PMID | 30100339 |
| PMC | PMC6108400 |
| MeSH | Aging / physiology* Animals Autophagy / physiology* Caenorhabditis elegans / physiology* Egg Yolk / metabolism* Intestines / physiology* Signal Transduction Vitellogenesis / physiology* |
| IF | 9.193 |
| 引用数 | 19 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 103 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm331 |