論文 - 詳細
| RRC ID | 55898 |
|---|---|
| 著者 | Eto S, Goto M, Soga M, Kaneko Y, Uehara Y, Mizuta H, Era T. |
| タイトル | Mesenchymal stem cells derived from human iPS cells via mesoderm and neuroepithelium have different features and therapeutic potentials. |
| ジャーナル | PLoS One |
| Abstract |
Mesenchymal stem cells (MSCs) isolated from adult human tissues are capable of proliferating in vitro and maintaining their multipotency, making them attractive cell sources for regenerative medicine. However, the availability and capability of self-renewal under current preparation regimes are limited. Induced pluripotent stem cells (iPSCs) now offer an alternative, similar cell source to MSCs. Herein, we established new methods for differentiating hiPSCs into MSCs via mesoderm-like and neuroepithelium-like cells. Both derived MSC populations exhibited self-renewal and multipotency, as well as therapeutic potential in mouse models of skin wounds, pressure ulcers, and osteoarthritis. Interestingly, the therapeutic effects differ between the two types of MSCs in the disease models, suggesting that the therapeutic effect depends on the cell origin. Our results provide valuable basic insights for the clinical application of such cells. |
| 巻・号 | 13(7) |
| ページ | e0200790 |
| 公開日 | 2018-7-25 |
| DOI | 10.1371/journal.pone.0200790 |
| PII | PONE-D-18-02372 |
| PMID | 30044827 |
| PMC | PMC6059447 |
| MeSH | Adipocytes / cytology Animals Cell Differentiation Disease Models, Animal Humans Induced Pluripotent Stem Cells / cytology* Male Mesenchymal Stem Cell Transplantation* Mesenchymal Stem Cells / cytology* Mesoderm / metabolism Mice Oligonucleotide Array Sequence Analysis Osteogenesis Regenerative Medicine / methods* Skin / metabolism |
| IF | 2.776 |
| 引用数 | 7 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | 201B7(HPS0063) |