| RRC ID |
55942
|
| 著者 |
Win NN, Woo SY, Ngwe H, Prema, Wong CP, Ito T, Okamoto Y, Tanaka M, Imagawa H, Asakawa Y, Abe I, Morita H.
|
| タイトル |
Tetrahydrofuran lignans: Melanogenesis inhibitors from Premna integrifolia wood collected in Myanmar.
|
| ジャーナル |
Fitoterapia
|
| Abstract |
Two new tetrahydrofuran lignans, taungtangyiols A (1) and B (2), and eight known furofuran lignans (3-10), were isolated from the chloroform extract of Premna integrifolia wood collected in Myanmar. Their structures were elucidated by extensive spectroscopic techniques. The X-ray crystal structure of 1 clearly indicated its relative configuration. Taungtangyiols A (1) and B (2) inhibited the deposition of melanin in B16F10 mouse melanoma cells, with IC50 values of 50.7 and 40.9 μM, respectively, without notable cytotoxicity. An SAR study demonstrated that the furofuran and dioxymethylene moieties of the lignans play a vital role in inhibiting melanogenesis.
|
| 巻・号 |
127
|
| ページ |
308-313
|
| 公開日 |
2018-6-1
|
| DOI |
10.1016/j.fitote.2018.03.002
|
| PII |
S0367-326X(18)30271-5
|
| PMID |
29540314
|
| MeSH |
Animals
Cell Line, Tumor
Furans / isolation & purification*
Lamiaceae / chemistry*
Lignans / isolation & purification*
Melanins / antagonists & inhibitors*
Melanoma, Experimental
Mice
Molecular Structure
Myanmar
Wood / chemistry*
|
| IF |
2.431
|
| 引用数 |
7
|
| リソース情報 |
| ヒト・動物細胞 |
B16F10/mGM(RCB1158) |
