| RRC ID |
55972
|
| 著者 |
Krtalić I, Radošević S, Hafner A, Grassi M, Nenadić M, Cetina-Čižmek B, Filipović-Grčić J, Pepić I, Lovrić J.
|
| タイトル |
D-Optimal Design in the Development of Rheologically Improved In Situ Forming Ophthalmic Gel.
|
| ジャーナル |
J Pharm Sci
|
| Abstract |
In situ forming ophthalmic gels need to be fine tuned considering all the biopharmaceutical challenges of the front of the eye in order to increase drug residence time at the application site resulting in its improved bioavailability and efficacy. The aim of this study was to develop in situ forming ophthalmic poloxamer P407/poloxamer P188/chitosan gel fine tuned in terms of polymer content, temperature of gelation, and viscosity. Minimizing the total polymer content while retaining the advantageous rheological properties has been achieved by means of D-optimal statistical design. The optimal in situ forming gel was selected based on minimal polymer content (P407, P188, and chitosan concentration of 14.2%, 1.7%, and 0.25% w/w, respectively), favorable rheological characteristics, and in vitro resistance to tear dilution. The optimal in situ forming gel was proved to be robust against entrapment of active pharmaceutical ingredients making it a suitable platform for ophthalmic delivery of active pharmaceutical ingredients with diverse physicochemical properties.
|
| 巻・号 |
107(6)
|
| ページ |
1562-1571
|
| 公開日 |
2018-6-1
|
| DOI |
10.1016/j.xphs.2018.01.019
|
| PII |
S0022-3549(18)30061-3
|
| PMID |
29421217
|
| MeSH |
Administration, Ophthalmic
Cell Line
Chitosan / chemistry*
Gels / chemistry*
Humans
Pharmaceutical Preparations / administration & dosage*
Pharmaceutical Vehicles / chemistry*
Poloxamer / chemistry*
Rheology
Temperature
Viscosity
|
| IF |
3.197
|
| 引用数 |
12
|
| リソース情報 |
| ヒト・動物細胞 |
HCE-T(RCB2280) |
