RRC ID 56094
Author Kiuchi J, Komatsu S, Imamura T, Nishibeppu K, Shoda K, Arita T, Kosuga T, Konishi H, Shiozaki A, Kubota T, Okamoto K, Fujiwara H, Ichikawa D, Tsuda H, Otsuji E.
Title Overexpression of YEATS4 contributes to malignant outcomes in gastric carcinoma.
Journal Am J Cancer Res
Abstract GC cells. Moreover, knockdown of YEATS4 improved chemosensitivity for CDDP and L-OHP. Overexpression of YEATS4 protein significantly correlated with more aggressive lymphatic invasion, larger tumor size, deeper tumor depth, positive lymph node metastasis and recurrence. Patients with YEATS4-overexpressing tumors had a lower overall survival rate than those with non-expressing tumors. Multivariate analysis demonstrated that YEATS4 was independently associated with poor outcomes. These findings suggest that YEATS4 plays a pivotal role in tumor malignant potential through its overexpression and highlight its usefulness as a prognostic factor and potential therapeutic target in GC.
Volume 8(12)
Pages 2436-2452
Published 2018
PMID 30662802
PMC PMC6325477
IF 3.998
Resource
Human and Animal Cells NUGC-4(RCB1939) HGC-27(RCB0500) MKN7(RCB0999) MKN45(RCB1001)