| RRC ID |
56112
|
| Author |
El-Beih AA, El-Desoky AH, Al-Hammady MA, Elshamy AI, Hegazy MF, Kato H, Tsukamoto S.
|
| Title |
New inhibitors of RANKL-induced Osteoclastogenesis from the marine sponge Siphonochalina siphonella.
|
| Journal |
Fitoterapia
|
| Abstract |
New sipholane type triterpenes, sipholenols N and O (1 and 2) and neviotine D (3), were isolated from the Red Sea marine sponge Siphonochalina siphonella along with four known triterpenes, sipholenone A (4), sipholenol A (5), siphonellinol D (6) and neviotine A (7). Structure elucidation of 1-3 was achieved by extensive 1D and 2D NMR analyses. The isolated compounds were examined for the inhibition of RANKL induced osteoclastogenesis in RAW264 macrophages. Neviotine D (3) and neviotine A (4) showed potent inhibition with IC50 values of 12.8 and 32.8 μM, respectively.
|
| Volume |
128
|
| Pages |
43-49
|
| Published |
2018-7-1
|
| DOI |
10.1016/j.fitote.2018.05.001
|
| PII |
S0367-326X(18)30500-8
|
| PMID |
29729401
|
| MeSH |
Animals
Callyspongia / chemistry*
Indian Ocean
Mice
Molecular Structure
Osteogenesis / drug effects*
RANK Ligand
RAW 264.7 Cells
Triterpenes / pharmacology*
|
| IF |
2.431
|
| Times Cited |
4
|
| Resource |
| Human and Animal Cells |
RAW 264(RCB0535) |
