論文 - 詳細
| RRC ID | 56114 |
|---|---|
| 著者 | Kawabata K, Baba N, Sakano T, Hamano Y, Taira S, Tamura A, Baba S, Natsume M, Ishii T, Murakami S, Ohigashi H. |
| タイトル | Functional properties of anti-inflammatory substances from quercetin-treated Bifidobacterium adolescentis. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
The genus Bifidobacterium is well known to have beneficial health effects. We discovered that quercetin and related polyphenols enhanced the secretion of anti-inflammatory substances by Bifidobacterium adolescentis. This study investigated characteristics of the anti-inflammatory substances secreted by B. adolescentis. The culture supernatant of B. adolescentis with quercetin reduced the levels of inflammatory mediators in activated macrophages. Spontaneous quercetin degradant failed to increase anti-inflammatory activity, while the enhancement of anti-inflammatory activity by quercetin was sustained after washout of quercetin. Physicochemical treatment of the culture supernatant indicated that its bioactive substances may be heat-stable, non-phenolic, and acidic biomolecules with molecular weights less than 3 kDa. Acetate and lactate have little or no effect on nitric oxide production. Taken together, the anti-inflammatory substances secreted by B. adolescentis may be small molecules but not short chain fatty acids. In agreement with these findings, stearic acid was tentatively identified as a bioactive candidate compound. |
| 巻・号 | 82(4) |
| ページ | 689-697 |
| 公開日 | 2018-4-1 |
| DOI | 10.1080/09168451.2017.1401916 |
| PMID | 29165050 |
| MeSH | Acetates / metabolism Animals Anti-Inflammatory Agents / chemistry Anti-Inflammatory Agents / isolation & purification Anti-Inflammatory Agents / pharmacology* Bifidobacterium adolescentis / drug effects* Bifidobacterium adolescentis / metabolism Blotting, Western Cell Line Chromatography, Liquid Culture Media Functional Food* Inflammation Mediators / antagonists & inhibitors Inflammation Mediators / metabolism Lactates / metabolism Lipopolysaccharides / pharmacology Mass Spectrometry Mice Molecular Weight Nitric Oxide / antagonists & inhibitors Nitric Oxide / biosynthesis Quercetin / pharmacology* Stearic Acids / pharmacology |
| IF | 1.297 |
| 引用数 | 4 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |