RRC ID 56127
Author Hashimoto C, Miki Y, Tanaka S, Takagi K, Fue M, Doe Z, Li B, Yaegashi N, Suzuki T, Ito K.
Title 17β-Hydroxysteroid Dehydrogenase Type 2 Expression Is Induced by Androgen Signaling in Endometrial Cancer.
Journal Int J Mol Sci
Abstract mRNA and protein expression in HEC-1B endometrial cancer cells. DHT could also inhibit cell proliferation of HEC-1B when induced by estradiol treatment. In 19 endometrioid endometrial adenocarcinoma (EEA) tissues, intratumoral DHT concentration was measured by liquid chromatography/electrospray tandem mass spectrometry and was found to be significantly correlated with 17β-HSD2 immunohistochemical status. We further examined the correlations between 17β-HSD2 immunoreactivity and clinicopathological parameters in 53 EEA tissues. 17β-HSD2 status was inversely associated with the histological grade, clinical stage, and cell proliferation marker Ki-67, and positively correlated with progesterone receptor expression. 17β-HSD2 status tended to be positively associated with androgen receptor status. In 53 EEA cases, the 17β-HSD2-positive group tended to have better prognosis than that for the negative group with respect to progression-free survival and endometrial cancer-specific survival. These findings suggest that androgen suppresses the estrogen dependence of endometrial cancer through the induction of 17β-HSD2 in endometrial cancer.
Volume 19(4)
Published 2018-4-10
DOI 10.3390/ijms19041139
PII ijms19041139
PMID 29642629
PMC PMC5979403
MeSH Aged Androgens / metabolism Androgens / pharmacology* Carcinoma, Endometrioid / metabolism* Carcinoma, Endometrioid / pathology Cell Line, Tumor Cell Proliferation / drug effects Dihydrotestosterone / metabolism Dihydrotestosterone / pharmacology* Endometrial Neoplasms / metabolism* Endometrial Neoplasms / pathology Estradiol Dehydrogenases / genetics Estradiol Dehydrogenases / metabolism* Female Humans Middle Aged RNA, Messenger / genetics RNA, Messenger / metabolism Signal Transduction*
IF 3.687
Human and Animal Cells Sawano(RCB1152)