論文 - 詳細
RRC ID | 56145 |
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著者 | Mashiba R, Ishikawa M, Sumiya YU, Kawakatsu K, Tran NK, Nishikata T. |
タイトル | Phagocytic Activation of Macrophages with Serum MAF Depends on Engulfment Efficiency and Not Migratory Activity. |
ジャーナル | Anticancer Res |
Abstract |
BACKGROUND/AIM:Serum-derived macrophage activating factor (serum MAF) is known to increase the phagocytic activity of macrophages and potentially plays a role in activating cancer immunity. In order to reveal the contributing factors for phagocytic activation, the migratory activity and the efficiency of engulfment was analyzed. MATERIALS AND METHODS:THP-1 macrophages were induced by 12-O-tetradecanoyl-13-acetate (TPA). The migratory activity and efficiency of engulfment were analyzed by time-lapse imaging and suspension assay, respectively. RESULTS:While the distance of migration did not change before and after activation with serum MAF, the efficiency of beads internalisation was significantly increased. CONCLUSION:Phagocytic activation of serum-MAF-treated macrophages was caused by increasing the efficiency of engulfment. This study contributes to the knowledge about the activation of the immune system through phagocytic activation of macrophages. |
巻・号 | 38(7) |
ページ | 4295-4298 |
公開日 | 2018-7-1 |
DOI | 10.21873/anticanres.12727 |
PII | 38/7/4295 |
PMID | 29970564 |
MeSH | Cell Line Humans Macrophage Activation / drug effects* Macrophage Activation / immunology* Macrophage Activation / physiology Macrophage-Activating Factors / pharmacology* Macrophages / drug effects* Macrophages / immunology* Phagocytosis / physiology* |
IF | 1.935 |
引用数 | 2 |
リソース情報 | |
ヒト・動物細胞 | THP-1(RCB1189) |