RRC ID 56153
Author Ito T, Rakainsa SK, Nisa K, Morita H.
Title Three new abietane-type diterpenoids from the leaves of Indonesian Plectranthus scutellarioides.
Journal Fitoterapia
Abstract Three new diterpenoids, spiroscutelones A-C (1-3), along with known diterpene 4, were isolated from the leaves of Plectranthus scutellarioides. Their structures were established based on extensive spectroscopic analyses, including MS and NMR spectroscopy. Spiroscutelone A (1) represents the first example of an abietane-type terpenoid skeleton with a cyclobutane moiety linking the B and C rings. Of compounds 1-4, spiroscutelone B (2) exhibited the most potent cytotoxicities against the three tested human cancer lines [breast (MCF-7), pancreatic (PSN-1), and cervical (HeLa)] with IC50 values ranging from 17.9 μM to 29.8 μM and low cytotoxicity against a lung fibroblast (WI-38) normal cell line.
Volume 127
Pages 146-150
Published 2018-6-1
DOI 10.1016/j.fitote.2018.02.013
PII S0367-326X(18)30043-1
PMID 29447983
MeSH Abietanes / isolation & purification* Abietanes / pharmacology Antineoplastic Agents, Phytogenic / isolation & purification Antineoplastic Agents, Phytogenic / pharmacology Cell Line, Tumor Humans Molecular Structure Plant Leaves / chemistry* Plectranthus / chemistry*
IF 2.431
Times Cited 2
Human and Animal Cells WI-38(RCB0704) MCF7(RCB1904) HeLs