論文 - 詳細
| RRC ID | 56153 |
|---|---|
| 著者 | Ito T, Rakainsa SK, Nisa K, Morita H. |
| タイトル | Three new abietane-type diterpenoids from the leaves of Indonesian Plectranthus scutellarioides. |
| ジャーナル | Fitoterapia |
| Abstract |
Three new diterpenoids, spiroscutelones A-C (1-3), along with known diterpene 4, were isolated from the leaves of Plectranthus scutellarioides. Their structures were established based on extensive spectroscopic analyses, including MS and NMR spectroscopy. Spiroscutelone A (1) represents the first example of an abietane-type terpenoid skeleton with a cyclobutane moiety linking the B and C rings. Of compounds 1-4, spiroscutelone B (2) exhibited the most potent cytotoxicities against the three tested human cancer lines [breast (MCF-7), pancreatic (PSN-1), and cervical (HeLa)] with IC50 values ranging from 17.9 μM to 29.8 μM and low cytotoxicity against a lung fibroblast (WI-38) normal cell line. |
| 巻・号 | 127 |
| ページ | 146-150 |
| 公開日 | 2018-6-1 |
| DOI | 10.1016/j.fitote.2018.02.013 |
| PII | S0367-326X(18)30043-1 |
| PMID | 29447983 |
| MeSH | Abietanes / isolation & purification* Abietanes / pharmacology Antineoplastic Agents, Phytogenic / isolation & purification Antineoplastic Agents, Phytogenic / pharmacology Cell Line, Tumor Humans Molecular Structure Plant Leaves / chemistry* Plectranthus / chemistry* |
| IF | 2.431 |
| 引用数 | 2 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | WI-38(RCB0704) MCF7(RCB1904) HeLs |