| RRC ID |
56153
|
| 著者 |
Ito T, Rakainsa SK, Nisa K, Morita H.
|
| タイトル |
Three new abietane-type diterpenoids from the leaves of Indonesian Plectranthus scutellarioides.
|
| ジャーナル |
Fitoterapia
|
| Abstract |
Three new diterpenoids, spiroscutelones A-C (1-3), along with known diterpene 4, were isolated from the leaves of Plectranthus scutellarioides. Their structures were established based on extensive spectroscopic analyses, including MS and NMR spectroscopy. Spiroscutelone A (1) represents the first example of an abietane-type terpenoid skeleton with a cyclobutane moiety linking the B and C rings. Of compounds 1-4, spiroscutelone B (2) exhibited the most potent cytotoxicities against the three tested human cancer lines [breast (MCF-7), pancreatic (PSN-1), and cervical (HeLa)] with IC50 values ranging from 17.9 μM to 29.8 μM and low cytotoxicity against a lung fibroblast (WI-38) normal cell line.
|
| 巻・号 |
127
|
| ページ |
146-150
|
| 公開日 |
2018-6-1
|
| DOI |
10.1016/j.fitote.2018.02.013
|
| PII |
S0367-326X(18)30043-1
|
| PMID |
29447983
|
| MeSH |
Abietanes / isolation & purification*
Abietanes / pharmacology
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology
Cell Line, Tumor
Humans
Molecular Structure
Plant Leaves / chemistry*
Plectranthus / chemistry*
|
| IF |
2.431
|
| 引用数 |
2
|
| リソース情報 |
| ヒト・動物細胞 |
WI-38(RCB0704)
MCF7(RCB1904)
HeLs |
