Reference - Detail
| RRC ID | 56177 |
|---|---|
| Author | Kang D, Kirienko DR, Webster P, Fisher AL, Kirienko NV. |
| Title | Pyoverdine, a siderophore from Pseudomonas aeruginosa, translocates into C. elegans, removes iron, and activates a distinct host response. |
| Journal | Virulence |
| Abstract |
Pseudomonas aeruginosa, a re-emerging, opportunistic human pathogen, encodes a variety of virulence determinants. Pyoverdine, a siderophore produced by this bacterium, is essential for pathogenesis in mammalian infections. This observation is generally attributed to its roles in acquiring iron and/or regulating other virulence factors. Here we report that pyoverdine translocates into the host, where it binds and extracts iron. Pyoverdine-mediated iron extraction damages host mitochondria, disrupting their function and triggering mitochondrial turnover via autophagy. The host detects this damage via a conserved mitochondrial surveillance pathway mediated by the ESRE network. Our findings illuminate the pathogenic mechanisms of pyoverdine and highlight the importance of this bacterial product in host-pathogen interactions. |
| Volume | 9(1) |
| Pages | 804-817 |
| Published | 2018-12-31 |
| DOI | 10.1080/21505594.2018.1449508 |
| PMID | 29532717 |
| PMC | PMC5955448 |
| MeSH | Animals Caenorhabditis elegans / microbiology* Host-Pathogen Interactions* Iron / metabolism* Mitochondria / metabolism Mitophagy Oligopeptides / metabolism* Pseudomonas aeruginosa / physiology* Siderophores / metabolism* Virulence Factors / metabolism* |
| IF | 4.775 |
| Times Cited | 19 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 10 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm1779 |