| RRC ID |
56177
|
| Author |
Kang D, Kirienko DR, Webster P, Fisher AL, Kirienko NV.
|
| Title |
Pyoverdine, a siderophore from Pseudomonas aeruginosa, translocates into C. elegans, removes iron, and activates a distinct host response.
|
| Journal |
Virulence
|
| Abstract |
Pseudomonas aeruginosa, a re-emerging, opportunistic human pathogen, encodes a variety of virulence determinants. Pyoverdine, a siderophore produced by this bacterium, is essential for pathogenesis in mammalian infections. This observation is generally attributed to its roles in acquiring iron and/or regulating other virulence factors. Here we report that pyoverdine translocates into the host, where it binds and extracts iron. Pyoverdine-mediated iron extraction damages host mitochondria, disrupting their function and triggering mitochondrial turnover via autophagy. The host detects this damage via a conserved mitochondrial surveillance pathway mediated by the ESRE network. Our findings illuminate the pathogenic mechanisms of pyoverdine and highlight the importance of this bacterial product in host-pathogen interactions.
|
| Volume |
9(1)
|
| Pages |
804-817
|
| Published |
2018-12-31
|
| DOI |
10.1080/21505594.2018.1449508
|
| PMID |
29532717
|
| PMC |
PMC5955448
|
| MeSH |
Animals
Caenorhabditis elegans / microbiology*
Host-Pathogen Interactions*
Iron / metabolism*
Mitochondria / metabolism
Mitophagy
Oligopeptides / metabolism*
Pseudomonas aeruginosa / physiology*
Siderophores / metabolism*
Virulence Factors / metabolism*
|
| IF |
4.775
|
| Times Cited |
19
|
| Resource |
| C.elegans |
tm1779 |
