Reference - Detail
| RRC ID | 56178 |
|---|---|
| Author | Kelley CA, Wirshing ACE, Zaidel-Bar R, Cram EJ. |
| Title | The myosin light-chain kinase MLCK-1 relocalizes during Caenorhabditis elegans ovulation to promote actomyosin bundle assembly and drive contraction. |
| Journal | Mol Biol Cell |
| Abstract |
We identify the Caenorhabditis elegans myosin light-chain kinase, MLCK-1, required for contraction of spermathecae. During contraction, MLCK-1 moves from the apical cell boundaries to the basal actomyosin bundles, where it stabilizes myosin downstream of calcium signaling. MLCK and ROCK act in distinct subsets of cells to coordinate the timing of contraction. |
| Volume | 29(16) |
| Pages | 1975-1991 |
| Published | 2018-8-8 |
| DOI | 10.1091/mbc.E18-01-0056 |
| PMID | 30088798 |
| PMC | PMC6232974 |
| MeSH | Actomyosin / metabolism* Amino Acid Sequence Animals Caenorhabditis elegans / cytology Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / chemistry Caenorhabditis elegans Proteins / metabolism* Female Fertility Humans Myosins / metabolism Ovulation* Phosphorylation Structural Homology, Protein |
| IF | 3.905 |
| Times Cited | 4 |
| Resource | |
| C.elegans | tm4159 |