論文 - 詳細
| RRC ID | 56184 |
|---|---|
| 著者 | King SD, Gray CF, Song L, Nechushtai R, Gumienny TL, Mittler R, Padilla PA. |
| タイトル | The cisd gene family regulates physiological germline apoptosis through ced-13 and the canonical cell death pathway in Caenorhabditis elegans. |
| ジャーナル | Cell Death Differ |
| Abstract |
Programmed cell death, which occurs through a conserved core molecular pathway, is important for fundamental developmental and homeostatic processes. The human iron-sulfur binding protein NAF-1/CISD2 binds to Bcl-2 and its disruption in cells leads to an increase in apoptosis. Other members of the CDGSH iron sulfur domain (CISD) family include mitoNEET/CISD1 and Miner2/CISD3. In humans, mutations in CISD2 result in Wolfram syndrome 2, a disease in which the patients display juvenile diabetes, neuropsychiatric disorders and defective platelet aggregation. The C. elegans genome contains three previously uncharacterized cisd genes that code for CISD-1, which has homology to mitoNEET/CISD1 and NAF-1/CISD2, and CISD-3.1 and CISD-3.2, both of which have homology to Miner2/CISD3. Disrupting the function of the cisd genes resulted in various germline abnormalities including distal tip cell migration defects and a significant increase in the number of cell corpses within the adult germline. This increased germ cell death is blocked by a gain-of-function mutation of the Bcl-2 homolog CED-9 and requires functional caspase CED-3 and the APAF-1 homolog CED-4. Furthermore, the increased germ cell death is facilitated by the pro-apoptotic, CED-9-binding protein CED-13, but not the related EGL-1 protein. This work is significant because it places the CISD family members as regulators of physiological germline programmed cell death acting through CED-13 and the core apoptotic machinery. |
| 巻・号 | 26(1) |
| ページ | 162-178 |
| 公開日 | 2019-1-1 |
| DOI | 10.1038/s41418-018-0108-5 |
| PII | 10.1038/s41418-018-0108-5 |
| PMID | 29666474 |
| PMC | PMC6294797 |
| MeSH | Animals Apoptosis / genetics* Apoptosis / physiology Caenorhabditis elegans / genetics* Caenorhabditis elegans Proteins / metabolism* Calcium-Binding Proteins / metabolism Caspases / metabolism Germ Cells / metabolism* Multigene Family Proto-Oncogene Proteins c-bcl-2 / metabolism |
| IF | 8.086 |
| 引用数 | 3 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 18 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm4993 |