論文 - 詳細
| RRC ID | 56210 |
|---|---|
| 著者 | Qu M, Xu K, Li Y, Wong G, Wang D. |
| タイトル | Using acs-22 mutant Caenorhabditis elegans to detect the toxicity of nanopolystyrene particles. |
| ジャーナル | Sci Total Environ |
| Abstract |
In this study, we employed Caenorhabditis elegans with acs-22 mutation to examine the in vivo effect of functional deficit in intestinal barrier on toxicity and translocation of nanopolystyrene particles. Mutation of acs-22 leads to deficit in intestinal barrier. After prolonged exposure, nanopolystyrene particles at concentrations ≥1 μg/L could cause toxicity on acs-22 mutant nematodes. acs-22 mutation resulted in translocation of nanopolystyrene particles into targeted organs through intestinal barrier in nanopolystyrene particles (1 μg/L) exposed nematodes. After prolonged exposure, nanopolystyrene particles (1 μg/L) dysregulated expressions of some genes required for the control of oxidative stress and activated expression of Nrf signaling pathway. Therefore, under certain pathological conditions, our results suggest the potential toxicity of nanoplastic particles at predicted environmental concentration on organisms after long-term exposure. |
| 巻・号 | 643 |
| ページ | 119-126 |
| 公開日 | 2018-12-1 |
| DOI | 10.1016/j.scitotenv.2018.06.173 |
| PII | S0048-9697(18)32249-6 |
| PMID | 29936155 |
| MeSH | Animals Biological Assay / methods Caenorhabditis elegans / genetics* Intestines Nanoparticles / toxicity* Oxidative Stress Polystyrenes / toxicity* Signal Transduction Toxicity Tests / methods* |
| IF | 5.589 |
| 引用数 | 33 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | |