RRC ID 56239
著者 Xiao G, Zhao L, Huang Q, Yang J, Du H, Guo D, Xia M, Li G, Chen Z, Wang D.
タイトル Toxicity evaluation of Wanzhou watershed of Yangtze Three Gorges Reservior in the flood season in Caenorhabditis elegans.
ジャーナル Sci Rep
Abstract Three Gorges Reservoir (TGR) in the upper stream of Yangtze River in China is a reservoir with the largest and the longest yearly water-level drop. Considering the fact that most of safety assessments of water samples collected from TGR region were based on chemical analysis, we here employed Caenorhabditis elegans to perform in vivo safety assessment of original surface water samples collected from TGR region in the flood season in Wanzhou, Chongqing. Among the examined five original surface water samples, only exposure to original surface water sample collected from backwater area could induce the significant intestinal ROS production, enhance the intestinal permeability, and decrease the locomotion behavior. Additionally, exposure to original surface water sample collected from backwater area altered the expressions of sod-2, sod-5, clk-1, and mev-1. Moreover, mutation of sod-2 or sod-5 was susceptible to the potential toxicity of original surface water sample collected from backwater area on nematodes. Together, our results imply that exposure to surface water sample from the backwater area may at least cause the adverse effects on intestinal function and locomotion behavior in nematodes.
巻・号 8(1)
ページ 6734
公開日 2018-4-30
DOI 10.1038/s41598-018-25048-w
PII 10.1038/s41598-018-25048-w
PMID 29712953
PMC PMC5928115
MeSH Animals Caenorhabditis elegans / chemistry Caenorhabditis elegans / drug effects China Environmental Monitoring* Floods / classification* Locomotion / drug effects* Rivers / chemistry Seasons Water Pollutants, Chemical / analysis*
IF 4.011
引用数 10
リソース情報
線虫 tm1146