Reference - Detail
| RRC ID | 56242 |
|---|---|
| Author | Yip ZC, Heiman MG. |
| Title | Ordered arrangement of dendrites within a C. elegans sensory nerve bundle. |
| Journal | Elife |
| Abstract |
Biological systems are organized into well-ordered structures and can evolve new patterns when perturbed. To identify principles underlying biological order, we turned to C. elegans for its simple anatomy and powerful genetics. We developed a method to quantify the arrangement of three dendrites in the main sensory nerve bundle, and found that they exhibit a stereotyped arrangement throughout larval growth. Dendrite order does not require prominent features including sensory cilia and glial junctions. In contrast, loss of the cell adhesion molecule (CAM) CDH-4/Fat-like cadherin causes dendrites to be ordered randomly, despite remaining bundled. Loss of the CAMs PTP-3/LAR or SAX-7/L1CAM causes dendrites to adopt an altered order, which becomes increasingly random as animals grow. Misexpression of SAX-7 leads to subtle but reproducible changes in dendrite order. Our results suggest that combinations of CAMs allow dendrites to self-organize into a stereotyped arrangement and can produce altered patterns when perturbed. |
| Volume | 7 |
| Published | 2018-8-20 |
| DOI | 10.7554/eLife.35825 |
| PII | 35825 |
| PMID | 30117807 |
| PMC | PMC6133548 |
| MeSH | Animals Cadherins / genetics* Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development Caenorhabditis elegans Proteins / genetics* Dendrites / genetics* Dendrites / physiology Gene Knockout Techniques Larva / genetics Larva / growth & development Nerve Net / growth & development Neural Cell Adhesion Molecules / genetics* Neuroglia / metabolism Neuroglia / physiology Olfactory Receptor Neurons / metabolism Olfactory Receptor Neurons / physiology Protein Tyrosine Phosphatases / genetics* Sensory Receptor Cells / metabolism Sensory Receptor Cells / physiology |
| IF | 7.551 |
| Times Cited | 4 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 14 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm2050 |