| RRC ID |
56262
|
| 著者 |
Hagiwara D, Takahashi H, Takagi H, Watanabe A, Kamei K.
|
| タイトル |
Heterogeneity in Pathogenicity-related Properties and Stress Tolerance in Aspergillus fumigatus Clinical Isolates.
|
| ジャーナル |
Med Mycol J
|
| Abstract |
Stress responses and pathogenicity have been extensively studied in Aspergillus fumigatus, the main causative pathogen of life-threatening aspergillosis. The heterogeneity in this pathogen's biology has recently attracted increasing attention. In the present work, we used 16 clinically isolated strains to investigate several properties relevant to the pathogenicity of A. fumigatus, namely, gliotoxin production, elastase activity, hypoxia growth, adaptation to iron-limiting conditions, and growth upon nitrosative, oxidative, and high osmotic stresses. The range of phenotypes was diverse across the strains, with gliotoxin production and elastase activity being negatively correlated at an intermediate index (R=-0.4717). Notably, there were strains that showed extraordinary high production of gliotoxin or elastase activity and hypersensitivity to nitrosative or oxidative stresses. Clustering analysis showed that the 7 potentially pathogenicity-related phenotypes were not correlated with the genetic sub-group or pathotype. These results contribute to the growing awareness of the genetic and phenotypic diversity in A. fumigatus isolates.
|
| 巻・号 |
59(4)
|
| ページ |
E63-E70
|
| 公開日 |
2018-1-1
|
| DOI |
10.3314/mmj.18-00007
|
| PMID |
30504617
|
| MeSH |
Aspergillosis / microbiology*
Aspergillus fumigatus / genetics
Aspergillus fumigatus / growth & development*
Aspergillus fumigatus / metabolism
Aspergillus fumigatus / pathogenicity
Cluster Analysis
Gliotoxin / biosynthesis
Humans
Osmotic Pressure*
Oxidative Stress*
Pancreatic Elastase / metabolism
|
| リソース情報 |
| 病原真核微生物 |
病原真菌：IFM 55369, IFM 58026, IFM 58401, IFM 59016, IFM 60237, IFM 59365, IFM 59777, IFM 60514, IFM 61118, IFM 61407, IFM 61578, IFM 61610, IFM 62115, IFM 62516, IFM 54229 (=Af293) |
