RRC ID 56274
Author Kohashi S, Toyama T, Hashimoto N, Sakurai M, Kato J, Kikuchi T, Koda Y, Sugita K, Hasegawa N, Yarita K, Kamei K, Okamoto S, Mori T.
Title Sinusitis caused by Exserohilum rostratum after cord blood transplantation for myelodysplastic syndrome: A case report and literature review.
Journal Transpl Infect Dis
Abstract Invasive fungal disease is a serious infectious complication of allogeneic hematopoietic stem cell transplantation (HSCT). Exserohilum rostratum is a species causing phaeohyphomycosis, which rarely causes invasive disease in humans. We treated a case of sinusitis caused by E. rostratum after cord blood transplantation (CBT). A 60-year-old man with myelodysplastic syndrome, who had a medical history of an operation to correct deviation of the nasal septum, developed sinusitis caused by E. rostratum under prolonged profound neutropenia after a second CBT because of the graft rejection of the first transplantation. Liposomal amphotericin B improved the sinusitis. A literature review revealed nine reported cases of sinusitis caused by E. rostratum, including our case. Although five cases had severe neutropenia at onset (HSCT recipients, n = 2; aplastic anemia, n = 3), the remaining four had no preexisting immunosuppressive conditions. However, three of the four patients had preexisting nasal diseases with or without a history of surgery, as in our case. Excluding our case, the outcome was fatal in five neutropenic patients, whereas the four patients without neutropenia recovered. Although sinusitis caused by E. rostratum is rare, E. rostratum should be recognized as a possible pathogen causing sinusitis in highly immunosuppressed patients such as HSCT recipients. Preexisting nasal disease and/or nasal surgery could be risks for this infection.
Volume 20(1)
Published 2018-2-1
DOI 10.1111/tid.12805
PMID 29119669
MeSH Adolescent Amphotericin B / therapeutic use Anemia, Aplastic Antifungal Agents / therapeutic use Ascomycota / isolation & purification* Bone Marrow Transplantation / adverse effects Child Child, Preschool Female Fetal Blood Hematopoietic Stem Cell Transplantation / adverse effects* Humans Immunocompromised Host Male Middle Aged Mycoses / drug therapy Mycoses / etiology Mycoses / microbiology Myelodysplastic Syndromes / complications* Myelodysplastic Syndromes / microbiology Myelodysplastic Syndromes / therapy Neutropenia / complications Neutropenia / microbiology Sinusitis / microbiology* Young Adult
IF 2.112
Times Cited 0
Pathogenic eukaryotic microorganisms 病原真菌:IFM 60242